Met-enk forming enzyme

cleaves Met-Thr bond from beta-endorphin to form Met-enkephalin; forms Met-enkephalin from alpha-endorphin & Leu-enkephalin from synthetic precursor; has chymotrypsin-like, trypsin-like & glutamyl-carboxyl cleaving activity

Also Known As:

enkephalin-generating enzyme; methionine enkephalin forming enzyme

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Peptide Hydrolases: 23957
      - Endopeptidases: 633
        Met-enk forming enzyme: 1

Related Diseases

Glioma (Gliomas)

02/26/1993 - "Moreover, when a partially purified preparation of enkephalin-generating enzyme secreted by glioma C6 cells was submitted to immunoblotting, an antiserum against purified brain endopeptidase 22.19 recognized a single band at Mr of 71 KDa. These data suggest that the soluble endopeptidase 22.19 may be secreted by glioma C6 cells thus allowing its participation in the biotransformation of opioid peptides in the CNS."

Related Drugs and Biologics

1.	Opioid Peptides (Opioid Peptide)
2.	thimet oligopeptidase (endo-oligopeptidase)