11-hydroxy-5,8,12,14-eicosatetraenoic acid

RN given refers to cpd without isomeric designation

Also Known As:

11-HETE; 11-hydroxy-5,8,12,14-eicosatetraenoic acid, (E,Z,Z,Z)-isomer; 11-hydroxy-5,8,12,14-eicosatetraenoic acid, (R)-(E,Z,Z,Z)-isomer; 11-hydroxy-5,8,12,14-eicosatetraenoic acid, (S)-(E,Z,Z,Z)-isomer

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Arachidonic Acids: 122
        Hydroxyeicosatetraenoic Acids: 318
        11-hydroxy-5,8,12,14-eicosatetraenoic acid: 12
    - Essential Fatty Acids: 734
      - Arachidonic Acids: 122
        Hydroxyeicosatetraenoic Acids: 318
        11-hydroxy-5,8,12,14-eicosatetraenoic acid: 12

Experts

1.	Fenton, Jenifer I: 2 articles (01/2019 - 01/2017)
2.	Sordillo, Lorraine M: 2 articles (01/2019 - 01/2017)
3.	Chen, Chen: 1 article (12/2019)
4.	Dai, Meiyan: 1 article (12/2019)
5.	Li, Huihui: 1 article (12/2019)
6.	Wang, Daowen: 1 article (12/2019)
7.	Wang, Wei: 1 article (12/2019)
8.	Wu, Lujin: 1 article (12/2019)
9.	Austin Pickens, C: 1 article (01/2019)
10.	Yin, Zhe: 1 article (01/2019)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 12/02/2019 - "In this study, we found that the degrees of inhibition on LC growth and metastasis by PPARα ligands depended on their bidirectional regulation on EETs and 11-HETE. " 12/02/2019 - "The COX inhibitor indomethacin strengthened the inhibitory actions of AVE8134 on tumour growth and metastasis by inhibiting the 11-HETE production in vivo and in vitro. "
2.	Inflammation (Inflammations) 08/22/2023 - "In contrast, lipid mediators involved in the reduction/resolution of inflammation, in particular, 5-HETE, 11-HETE, and 5-oxoETE, were significantly elevated in mild/moderate disease. " 01/01/2013 - "Levels of PGE2, PGD2, TXB2, 5-HETE, 11-HETE, 12-HETE and 15-HETE are significantly elevated in inflamed mucosa and correlate with severity of inflammation, determined using validated histological scoring systems. "
3.	Atherosclerotic Plaque (Atheroma) 05/15/2001 - "Identification and quantitation was performed using HPLC and GC-MS. High levels of hydroxyoctadecanoic acids (0.51 +/- 0.17 ng/microg of linoleic acid), 15-hydroxyeicosatetranoic acid (HETE) (0.66 +/- 0.24 ng/microg of arachidonic acid), and 11-HETE (0.84 +/- 0.24 ng/microg of arachidonic acid) were detected in all atherosclerotic plaques (n = 10). "
4.	Autosomal Dominant Polycystic Kidney (ADPKD) 01/01/2014 - "ADPKD patients with eGFR >60 ml/min/1.73 m(2) showed higher levels of 5- and 12/15-lipoxygenase (LOX) and cyclooxygenase, and generated higher levels of hydroxy-octadecadienoic acids 9-HODE and 13-HODE and HETEs 8-HETE, 11-HETE, 12-HETE, and 15-HETE as compared with healthy subjects. "
5.	Polyps 01/01/2019 - "Concentrations of 5-hydroxyeicosatetraenoic acid (HETE) and 11-HETE were significantly higher in those with hyperplastic polyps and adenomas compared to those with no polyps. "

Related Drugs and Biologics

1.	Ligands
2.	5-hydroxy-6,8,11,14-eicosatetraenoic acid
3.	Acids
4.	15-hydroxy-5,8,11,13-eicosatetraenoic acid
5.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
6.	Dinoprostone (PGE2)
7.	Hydroxyeicosatetraenoic Acids (HETE)
8.	13-hydroxy-9,11-octadecadienoic acid
9.	Oxylipins
10.	Linoleic Acid (Linoleate)