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7-N-(4-hydroxyphenyl)mitomycin C
Also Known As:
7-N-(p-hydroxyphenyl)-mitomycin C; 7-N-PHPMC; KW 2083; NSC 278891; NSC-278891; Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6-((4-hydroxyphenyl)amino)-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))-
Networked:
12
relevant articles (
0
outcomes,
3
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Quinones: 434
Indolequinones: 12
Mitomycins: 11
7-N-(4-hydroxyphenyl)mitomycin C: 12
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azirines
Mitomycins: 11
7-N-(4-hydroxyphenyl)mitomycin C: 12
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Indolequinones: 12
Mitomycins: 11
7-N-(4-hydroxyphenyl)mitomycin C: 12
Related Diseases
1.
Neoplasms (Cancer)
09/01/1983 - "
Grade IIA histological alterations of tumor cells by Oboshi and Shimosato's Classification such as vacuolation of cytoplasm and pyknosis of nuclei were noted after KW 2083 infusion.
"
09/01/1983 - "
It is worth mentioning that the concentration of KW 2083 in tumor tissue of the stomach of experimental dog after right gastroepiploic arterial infusion was twice as high as that in intact gastric wall.
"
12/01/1981 - "
Antitumor activity of 7-n-(p-hydroxyphenyl)-mitomycin C in experimental tumor systems.
"
03/01/1985 - "
Phase II study of 7-N-(p-hydroxyphenyl)-mitomycin C (KW2083) in patients with advanced non-small cell carcinoma of the lung and metastatic pulmonary tumors.
"
12/01/1984 - "
[Phase II study of KW 2083 [7-N-(p-hydroxyphenyl)-mitomycin C] in patients with various cancers].
"
2.
Stomach Neoplasms (Stomach Cancer)
12/01/1985 - "
In this study, eight beagle dogs with gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) received weekly administration of 7-N-(p-hydroxyphenyl)-mitomycin C (M-83), a variant of mitomycin C.
"
12/01/1984 - "
A phase II study of KW 2083 [7-N-(p-Hydroxyphenyl)-Mitomycin C] was carried out in 14 cases of stomach cancer, 5 of lung cancer, 5 of colon cancer and 5 other types of cancer.
"
3.
Lung Neoplasms (Lung Cancer)
12/01/1984 - "
A phase II study of KW 2083 [7-N-(p-Hydroxyphenyl)-Mitomycin C] was carried out in 14 cases of stomach cancer, 5 of lung cancer, 5 of colon cancer and 5 other types of cancer.
"
06/01/1984 - "
Fourteen cases of adenocarcinoma with pleuritis carcinomatosa (lung cancer 10 cases, ovarian cancer 2 cases, colon cancer 2 cases) were treated with intra-pleural instillation of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083), a derivative of mitomycin C.
"
4.
Colonic Neoplasms (Colon Cancer)
12/01/1984 - "
A phase II study of KW 2083 [7-N-(p-Hydroxyphenyl)-Mitomycin C] was carried out in 14 cases of stomach cancer, 5 of lung cancer, 5 of colon cancer and 5 other types of cancer.
"
06/01/1984 - "
Fourteen cases of adenocarcinoma with pleuritis carcinomatosa (lung cancer 10 cases, ovarian cancer 2 cases, colon cancer 2 cases) were treated with intra-pleural instillation of 7-N-(p-hydroxyphenyl)-mitomycin C (KW-2083), a derivative of mitomycin C.
"
5.
Small Cell Carcinoma
03/01/1985 - "
Phase II study of 7-N-(p-hydroxyphenyl)-mitomycin C (KW2083) in patients with advanced non-small cell carcinoma of the lung and metastatic pulmonary tumors.
"
03/01/1985 - "
Twenty-six patients with non-small cell carcinoma of the lung and 25 with metastatic pulmonary tumors were treated by intravenous injection of 7-N-(p-hydroxyphenyl)-mitomycin C (KW2083), a derivative of mitomycin C, either at a single 70-mg/m2 dose or at a dose of 20-30 mg/m2 once a week for 3 weeks.
"
Related Drugs and Biologics
1.
Mitomycin (Mitomycin-C)
2.
ENNG
3.
7-N-(4-hydroxyphenyl)mitomycin C
4.
Antineoplastic Agents (Antineoplastics)
Related Therapies and Procedures
1.
Intravenous Injections