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germacrene D

RN in 9th CI Form Index for unspecified stereoisomer: 37839-63-7

Also Known As:

germacrene D, (S-(E,E))-isomer

Networked: 13 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Monocyclic Sesquiterpenes: 14
        Germacrane Sesquiterpenes: 1
        germacrene D: 13

Experts

1.	Figueiredo, Carlos R: 2 articles (04/2018 - 02/2013)
2.	Lago, João Henrique G: 2 articles (04/2018 - 02/2013)
3.	Cardoso, Claudia Andrea Lima: 1 article (10/2022)
4.	Dos Santos Yamazaki, Diego Alberto: 1 article (10/2022)
5.	Formagio, Anelise Samara Nazari: 1 article (10/2022)
6.	Kassuya, Candida Aparecida Leite: 1 article (10/2022)
7.	Manfron, Jane: 1 article (10/2022)
8.	Marangoni, Janaine Alberto: 1 article (10/2022)
9.	Pereira, Zefa Valdevina: 1 article (10/2022)
10.	Silva, Rosilda Mara Mussury Franco: 1 article (10/2022)

Related Diseases

1.	Infections 05/01/2022 - "Furthermore, FaTPS1 overexpression increased the emission of sesquiterpenes, especially germacrene D, and improved strawberry resistance against Botrytis cinerea infection, although the knockdown of FaTPS1 increased its susceptibility to the same pathogen. " 08/01/2002 - "purpurea roots, were identified in the GC-MS traces of the analyzed fractions and efficiently separated in a turnaround time of 25 min. CMV infection was found to be responsible for significant variations in the relative compositions of the major constituents, in particular germacrene D, Dodeca-2E, 4E, 8Z, 10Z(E)-tetraenoic acid isobutylamide cis/trans isomers, Undeca-2Z, 4E-diene-8, 10-diynoic acid isobutylamide and Dodeca-2E, 4Z-diene-8, 10-diynoic acid isobutylamide." 01/01/2021 - "Germacrene D and sativene, which were associated with FHB infection, and mellein and heptadecanone, which were associated with SNB infection, were consistently emitted by both wheat varieties. " 08/01/2020 - "Uninfected plants emitted higher amounts of volatiles than infected plants, particularly (E)-4,8-dimethyl-1, 3, 7-nonatriene, dodecane, and germacrene-D; however, we observed no effect of infection on phytohormone levels. "
2.	Neoplasms (Cancer) 02/01/2013 - "These results suggested that the crudeoils and their components, mainly germacrene D, could be used as prototypes for the development of new anti-cancer agents for the treatment of human leukemia." 04/01/2023 - "Literature data, dealing with the biological activities of the main oil constituents, highlighted an anti-microbial, anti-inflammatory, and anti-tumor potential, due to the high content in sesquiterpenes and, particularly, of β-caryophyllene and germacrene D." 04/01/2018 - "Evaluation of in vitro cytotoxicity against several cancer and non-tumourigenic cells indicated promising activity, especially to HeLa (human cervical carcinoma) with IC50 ranging from 11 ± 3 to 17 ± 3 μg/mL. The obtained volatile oils were pooled and subjected to fractionation to afford pure β-caryophyllene, α-chamigrene and germacrene D, being this last compound the more active against HeLa cells with IC50 of 7 ± 1 μg/mL (34 ± 5 μM). " 05/01/2015 - "brasiliensis presents trans-nerolidol, germacrene D, trans-caryophyllene, α-humulene, and farnesene as major constituents and is able to inhibit cell proliferation in cultures as well as in tumor growth in mice. "
3.	Tics (Tic) 01/22/2021 - "The acquired quantities based on total ion current (TIC) showed that the regenerated plantlets using 1 mg L-1 NAA produced higher amounts of oxygenated monoterpenes such as camphor (30.29%), cis-thujone (7.07%), and 1,8-cineole (6.71%) and sesquiterpene derivatives, namely germacrene D (8.75%), bicyclogermacrene (4.0%) and spathulenol (1.49%) compared with the intact plant. "
4.	Leukemia 02/01/2013 - "These results suggested that the crudeoils and their components, mainly germacrene D, could be used as prototypes for the development of new anti-cancer agents for the treatment of human leukemia."
5.	Hyperalgesia 10/05/2022 - "The inflammatory parameters were evaluated using CFA model (with paw edema, mechanical, thermal hyperalgesia, MPO and NAG) in EOPP (30, 100 and 300 mg/kg), germacrene D and bicyclogermacrene (30 mg/kg). "

Related Drugs and Biologics

1.	Sesquiterpenes
2.	caryophyllene
3.	Monoterpenes (Monoterpenoids)
4.	Terpenes (Terpenoids)
5.	Plant Growth Regulators (Plant Hormones)
6.	Volatile Oils (Essential Oils)
7.	Eugenol
8.	Camphor
9.	Acids
10.	Eucalyptol