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N-acetyl-1-aspartylglutamic acid (NAAGA)

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mediator in the sensitivity of animals to hyperbaric oxygenation; Naaxia is the tradename; apparently can have both a neuroprotective and a neurotoxic effect

Also Known As:

NAAGA; N-acetylaspartylglutamate; N-acetyl-1-Asp-Glu; N-acetyl-1-aspartylglutamic acid, (L)-isomer ion; N-acetyl-1-aspartylglutamic acid, magnesium salt; N-acetyl-L-alpha-aspartylglutamic acid; N-acetyl-aspartyl-glutamate; N-acetyl-aspartyl-glutamic acid; NAAGA magnesium salt; NAAGA sodium salt; Naaxia; ZY 15106; ZY-15106; ZY15106; Zy 15109; Zy-15109; Zy15109

Networked: 87 relevant articles (8 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - Oligopeptides: 168
    - Dipeptides: 137
      - N-acetyl-1-aspartylglutamic acid: 87

Experts

1.	Moffett, John R: 7 articles (09/2013 - 04/2003)
2.	Neale, Joseph H: 7 articles (06/2012 - 07/2004)
3.	Bzdega, Tomasz: 4 articles (06/2012 - 09/2005)
4.	Yamamoto, Tatsuo: 4 articles (01/2012 - 07/2004)
5.	Namboodiri, Aryan M A: 3 articles (09/2013 - 08/2008)
6.	Olszewski, Rafal T: 3 articles (06/2012 - 09/2005)
7.	Kozikowski, Alan: 3 articles (01/2008 - 07/2004)
8.	Zhou, Jia: 3 articles (01/2008 - 07/2004)
9.	Wroblewska, Barbara: 3 articles (01/2007 - 07/2004)
10.	Rowland, Laura M: 2 articles (04/2015 - 09/2013)

Related Diseases

1.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 12/01/2008 - "In the moderate forms of seasonal and intra-annual allergic conjunctivitis, NAAGA treatment alone is sufficient. " 10/01/1998 - "While both lodoxamide and NAAGA treatments are associated with clinical improvements in patients with allergic conjunctivitis, lodoxamide may have an earlier onset of action." 12/01/2007 - "This comparative and randomised pilot study assessed the clinical and biological efficacy of Naaxia Sine(R) eye-drops versus levocabastine eye-drops in the treatment of vernal keratoconjunctivitis (VKC). " 12/01/2007 - "Clinical and biological efficacy of preservative-free NAAGA eye-drops versus levocabastine eye-drops in vernal keratoconjunctivitis patients." 01/01/1996 - "Efficacy of lodoxamide 0.1% versus N-acetyl aspartyl glutamic acid 6% ophthalmic solutions in patients with vernal keratoconjunctivitis."
2.	Rhinitis 11/15/1989 - "The object of the above study was to evaluate the tolerability and possible therapeutic use of MgNAAGA (Mg salt of N-acetyl-aspartyl-glutamic acid) in patients with allergic rhinitis. " 07/01/1997 - "In allergic rhinitis good clinical results are obtained using NAAGA. " 11/01/1993 - "The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction." 11/15/1989 - "[Evaluation of the efficacy of the magnesium salt of N-acetyl-aspartyl-glutamic acid in the treatment of acute rhinitis]." 09/01/1998 - "Ten patients with allergic seasonal rhinitis were included in this randomized double-blind crossover trial of a 6% wt/vol solution of NAAGA (daily dosage 84 mg) versus placebo (lactose). "
3.	Seasonal Allergic Rhinitis (Hay Fever) 09/01/1995 - "Clinical efficacy of N-acetyl-aspartyl-glutamic acid nasal spray in children suffering from pollinosis: a double-blind multicentre study." 08/01/1987 - "[Controlled study of a new anti-allergic agent, N-acetyl-aspartyl- glutamic acid (NAAGA), in the local treatment of pollinosis]." 03/01/1994 - "A gel formulation of the antiallergic compound N-acetyl-aspartyl glutamic acid (NAAGA) (Rhinaaxia (R)) has been evaluated in a multicenter, randomized, double-blind, three-arm, parallel-group comparison with placebo gel (P) and disodium cromoglycate (DSCG) in outpatients suffering from seasonal allergic rhinitis (pollinosis). " 03/01/1994 - "Nasal application of a gel formulation of N-acetyl-aspartyl glutamic acid (NAAGA) compared with placebo and disodium cromoglycate in the symptomatic treatment of pollinosis."
4.	Nasal Obstruction 11/01/1993 - "The results suggest that the favorable effect of the regular administration of NAAGA in allergic rhinitis is to be expected primarily when the main complaint is nasal obstruction." 09/01/1998 - "Treatment with NAAGA, but not with placebo, significantly reduced the late antigen-induced nasal symptoms, mainly nasal obstruction. " 11/01/1993 - "Pretreatment with NAAGA 1 h before NCT significantly (P < 0.001) attenuated antigen-induced nasal obstruction. " 01/01/1994 - "Treatment with ZY15106, but not with placebo, caused a significant reduction in nasal obstruction in the first 30 min after challenge and at 60 min and itching in the first 10 min after challenge, but did not reduce sneezing and rhinorrhoea. " 11/01/1993 - "Specific nasal challenge test (NCT) with pollen extracts was performed before and after a single dose pretreatment with N-acetyl-aspartyl-glutamate (NAAGA: Rhinaaxia) nasal spray in 11 grass- and ragweed-pollen-sensitive patients with allergic rhinitis in symptom-free condition to test the protective effect of this drug on allergen-induced nasal obstruction and symptoms. "
5.	Sneezing 01/01/1994 - "Treatment with ZY15106, but not with placebo, caused a significant reduction in nasal obstruction in the first 30 min after challenge and at 60 min and itching in the first 10 min after challenge, but did not reduce sneezing and rhinorrhoea. "

Related Drugs and Biologics

1.	N-acetyl-1-aspartylglutamic acid (NAAGA)
2.	Ophthalmic Solutions (Eye Drops)
3.	Magnesium
4.	lodoxamide ethyl (lodoxamide)
5.	levocabastine (Bilina)
6.	lodoxamide tromethamine (Alomide)
7.	N-acetylaspartate (N-acetyl aspartate)
8.	Glutamic Acid (Glutamate)
9.	Aspartic Acid (Aspartate)
10.	Endothelin-1 (Endothelin 1)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Analgesia