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digitalis receptor
Also Known As:
digitalis receptors; receptor, digitalis
Networked:
13
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Enzymes and Coenzymes: 1
Enzymes: 152586
Hydrolases: 2166
Acid Anhydride Hydrolases
Adenosine Triphosphatases: 8623
P-type ATPases: 226
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Carrier Proteins: 12999
Membrane Transport Proteins: 589
P-type ATPases: 226
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Ion Pumps: 61
Antiporters: 369
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Cation Transport Proteins: 22
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Membrane Proteins: 10078
Membrane Transport Proteins: 589
P-type ATPases: 226
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Ion Pumps: 61
Antiporters: 369
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Cation Transport Proteins: 22
Sodium-Potassium-Exchanging ATPase: 656
digitalis receptor: 13
Related Diseases
1.
Heart Failure
01/01/1997 - "
Canine cardiac digitalis receptors are preserved in congestive heart failure induced by rapid ventricular pacing.
"
05/01/1993 - "
This unexpected complexity of the digitalis receptor raises new questions about the role of digitalis glycosides in the treatment of congestive heart failure.
"
01/01/1993 - "
On this basis, digitalis receptor concentration was quantified in the left ventricle of explanted hearts from subjects without heart disease and from patients with end-stage heart failure who had received digitalis therapy.
"
01/01/1997 - "
The aim of this study was to evaluate if a similar change in the two canine digitalis receptor isoforms occurs following 4 weeks of rapid ventricular pacing-induced heart failure without profound necrosis.
"
01/01/1993 - "
No adaptation to digitalization as evaluated by digitalis receptor (Na,K-ATPase) quantification in explanted hearts from donors without heart disease and from digitalized recipients with end-stage heart failure.
"
2.
Necrosis
01/01/1997 - "
The aim of this study was to evaluate if a similar change in the two canine digitalis receptor isoforms occurs following 4 weeks of rapid ventricular pacing-induced heart failure without profound necrosis.
"
3.
Hypertension (High Blood Pressure)
05/01/1991 - "
An inhibitor of the Na+/K(+)-ATPase acting via the digitalis receptor - called digitalis like factor (DLF) - is regarded as the causative agent for the development of hypertension in these cases.
"
01/01/1987 - "
Of the few compounds currently identified as having "digitalis-like" activity, none appears to be the natural ligand of the digitalis receptor and none appears linked with hypertension.
"
12/21/1987 - "
Canrenone, a metabolic product of spironolactone which can compete with oubain for binding to Na+,K+-ATPase at the digitalis receptor site, decreases blood pressure in a low renin, volume expanded model of hypertension which has been shown to have depressed sodium pump activity in arteries and increased sodium pump inhibitor in plasma (reduced renal mass-saline rat) but has no effect on blood pressure in a genetic model of hypertension which has been shown to have increased sodium pump activity secondary to increased sodium permeability (spontaneously hypertensive rat).
"
4.
Aortic Valve Stenosis (Aortic Stenosis)
07/01/1984 - "
This change in the number of digitalis receptors was maintained between 4 and 8 weeks of aortic stenosis and may be an important adaptive mechanism.
"
07/01/1984 - "
Measurement of specific 3H-ouabain binding with sarcolemmal fraction isolated from hypertrophied heart revealed a 26% reduction of digitalis receptor after 4 weeks of aortic stenosis, without any significant change in the affinity of receptor sites.
"
11/01/1990 - "
The contribution of the heterogeneous digitalis receptors to the inotropic effect of ouabain was studied in hypertrophied rat hearts (aortic stenosis) by using isolated Langendorff heart preparations.
"
5.
Cardiotoxicity
04/01/1986 - "
In hypokalaemia the incidence of cardiac toxicity with digitalis is increased, possibly through changes in the affinity or capacity of the digitalis receptor in the heart.
"
Related Drugs and Biologics
1.
Protein Isoforms (Isoforms)
2.
Ouabain (G Strophanthin)
3.
Adenosine Triphosphatases (ATPase)
4.
Digoxin (Digitek)
5.
Spironolactone (Aldactone)
6.
Sodium
7.
Renin
8.
Ligands
9.
Digitalis Glycosides
10.
Cardiac Glycosides
Related Therapies and Procedures
1.
Therapeutics