cinepazide

Also Known As:

1-((1-pyrrolidinylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine; 1-((1-pyrrolidynylcarbonyl)methyl)-4-(3,4,5-trimethoxycinnamoyl)piperazine maleate; 67350-MD; MD-67350 free base; Vasodistal; cinepazide maleate; 2-Propen-1-one, 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)-1-piperazinyl)-3-(3,4,5-trimethoxyphenyl)-, (2E)-

Networked: 18 relevant articles (3 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperazines: 26
    - cinepazide: 18

Experts

1.	Zhang, Xiao: 2 articles (06/2014 - 10/2013)
2.	Zhao, Gang: 2 articles (06/2014 - 10/2013)
3.	Zhao, Jun: 2 articles (06/2014 - 10/2013)
4.	Shang, Yun: 1 article (01/2021)
5.	Zhang, Jing: 1 article (01/2021)
6.	Zhang, Li: 1 article (01/2021)
7.	Zhang, Xia: 1 article (01/2021)
8.	Cai, Xueli: 1 article (07/2020)
9.	Chen, Guofang: 1 article (07/2020)
10.	Chen, Huisheng: 1 article (07/2020)

Related Diseases

1.	Ischemic Stroke 08/01/2022 - "Methods: This was a subgroup analysis of post-marketing clinical confirmation study of cinepazide maleate injection for acute ischemic stroke: a randomized, double-blinded, multicenter, placebo-parallel controlled trial, which conducted in China from August 2016 to February 2019. " 07/14/2020 - "Therefore, this study aimed to further confirm the efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke. " 07/14/2020 - "Efficacy and safety of cinepazide maleate injection in patients with acute ischemic stroke: a multicenter, randomized, double-blind, placebo-controlled trial." 07/14/2020 - "The results of this study show that cinepazide maleate injection is superior to placebo in improving neurological function and activities of daily living, reducing disability, and promoting functional recovery in patients with acute ischemic stroke. " 07/14/2020 - "Patients with acute ischemic stroke were administered an intravenous infusion of 320 mg cinepazide maleate or placebo once daily for 14 days. "
2.	Stroke (Strokes) 07/14/2020 - "In China, cinepazide maleate injection has been shown to improve the cerebral collateral circulation and further reduce disability in stroke patients; however, very few studies investigating this therapy have been conducted to date. "
3.	Cerebral Infarction 10/01/2013 - "Mildronate injection is as effective and safe as cinepazide injection in treating acute cerebral infarction." 09/01/2014 - "The results showed that patients with more males than females (1.63: 1); age > 46 in older persons, treatment 7-14 days accounted for the majority of patients with hypertension, cerebral infarction, diabetes, coronary heart disease and other diseases; common drug combination can be divided into seven categories: medicine of antiplatelet therapy (aspirin, clopidogrel hydrogen), hypolipidemic drugs (atorvastatin, probucol), calcium channel blockers (cinepazide), cerebral protection drugs (laci staw), to improve cerebral circulation drugs (alprostadil), other traditional Chinese medicine injection (Shuxuetong injection, Xueshuantong), treatment with underlying disease: nifedipine, metoprolol, isosorbide dinitrate etc. The clinical cure rate and improvement rate of 97.60%. "
4.	Spinal Cord Injuries (Spinal Cord Injury) 06/01/2023 - "Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival." 06/01/2023 - "This study aimed to investigate the therapeutic effects of cinepazide maleate (CM) on spinal cord injury (SCI) in rats, thereby providing an experimental basis for the use of CM as a preventative and therapeutic strategy for SCI. Terminal deoxynucleotidyl transferase dUTP nick end labeling staining and western blot analysis were used to assess neural cell apoptosis. "
5.	Agranulocytosis (Granulocytopenia) 01/01/1990 - "Agranulocytosis induced by cinepazide." 01/01/1987 - "[Agranulocytosis caused by cinepazide maleate. " 11/01/1985 - "[Two cases of agranulocytosis during medication with cinepazide]."

Related Drugs and Biologics

1.	3-(2,2,2-trimethylhydrazine)propionate
2.	Therapeutic Uses
3.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
4.	Vasodilator Agents (Vasodilators)
5.	Dihydroergocristine
6.	Xanthinol Niacinate (Xavin)
7.	Moxisylyte (Thymoxamine)
8.	Serotonin (5 Hydroxytryptamine)
9.	Probucol (Lorelco)
10.	Piribedil (Trivastal)

Related Therapies and Procedures

1.	Therapeutics
2.	Activities of Daily Living (ADL)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Intravenous Infusions
5.	Oral Administration