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spirogermanium
RN given refers to parent cpd
Also Known As:
NSC 192965; NSC-192965; spirogermanium dihdyrochloride; 2-aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl-,
Networked:
52
relevant articles (
2
outcomes,
34
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Spiro Compounds: 2
spirogermanium: 52
Organometallic Compounds: 64
spirogermanium: 52
Polycyclic Compounds: 6
Spiro Compounds: 2
spirogermanium: 52
Related Diseases
1.
Neoplasms (Cancer)
01/01/1981 - "
In the present phase II trial 18 heavily pretreated patients with advanced ovarian malignancy were treated with spirogermanium, 11 im and seven iv. Objective responses (partial remission) were obtained in two (11%) of the 18 patients, with a remission duration of 5 and 23 + months, respectively.
"
06/01/1991 - "
Results of phases I and II human cancer trials for spirogermanium have not been favorable, with the exception of moderate benefits for three types of malignancies.
"
02/01/1990 - "
Thirty-three patients with advanced malignancy were treated with oral spirogermanium in a Phase I study to determine a maximum tolerated dose.
"
08/01/1988 - "
A phase II study of spirogermanium in advanced large bowel cancer.
"
08/01/1985 - "
A phase II study of spirogermanium in advanced human malignancy.
"
2.
Infections
08/01/1987 - "
Spirogermanium is an antineoplastic agent that has been shown to be useful for the treatment of a variety of solid tumors and Plasmodium falciparum infection.
"
3.
Carcinoma (Carcinomatosis)
01/01/1986 - "
A phase II study of spirogermanium was conducted in a series of 15 patients with metastatic prostatic carcinoma.
"
04/01/1985 - "
Phase II study of spirogermanium in patients with advanced carcinoma of the cervix.
"
01/01/1985 - "
Continuous-infusion spirogermanium for the treatment of refractory carcinoma of the ovary: a phase II trial.
"
08/01/1982 - "
Phase II trial of spirogermanium in advanced epithelial carcinoma of the ovary.
"
02/01/1983 - "
Phase II evaluation of spirogermanium in advanced ovarian carcinoma.
"
4.
Lymphoma (Lymphomas)
07/01/1989 - "
A phase II study of spirogermanium in patients with advanced malignant lymphoma.
"
07/01/1986 - "
Phase II Eastern Cooperative Oncology Group Study of spirogermanium in previously treated lymphoma.
"
01/01/1985 - "
The National Cancer Institute of Canada Clinical Trials Group conducted a phase II study of spirogermanium given daily for 5 days every 3 weeks to patients with poor prognosis non-Hodgkin's lymphomas.
"
01/01/1985 - "
There is no evidence of activity of spirogermanium given in this schedule in this subset of lymphoma patients.
"
01/01/1985 - "
A phase II study of spirogermanium as second line therapy in patients with poor prognosis lymphoma.
"
5.
Breast Neoplasms (Breast Cancer)
12/01/1984 - "
Phase II study of spirogermanium in advanced breast cancer.
"
09/01/1984 - "
Phase II study of spirogermanium in the treatment of metastatic breast cancer.
"
02/01/1983 - "
Phase II trial of spirogermanium for treatment of advanced breast cancer.
"
01/01/1986 - "
Spirogermanium was also able to overcome the multidrug resistance exhibited by the colchicine-resistant mutant CHRC5 cells and a subline of vincristine-resistant MCF-7 human breast carcinoma cells, following 1 or 24 hour drug treatments.
"
Related Drugs and Biologics
1.
Antineoplastic Agents (Antineoplastics)
2.
spirogermanium
3.
methylformamide
4.
Cytostatic Agents
5.
Idarubicin (4 Demethoxydaunorubicin)
6.
Vindesine (Vindesin)
7.
Gallium
8.
Etoposide (VP 16)
9.
aclacinomycins
10.
Germanium
Related Therapies and Procedures
1.
Therapeutics
2.
Drug Therapy (Chemotherapy)
3.
Lymphatic Irradiation
4.
Radiotherapy
5.
Oral Administration