meizothrombin

precursor of alpha-thrombin in the conversion of prothrombin to alpha-thrombin; has esterase activity; meizothrombin-(des F1) produced by reaction of prethrombin-1 with Echis carinatus Venom

Also Known As:

Networked: 17 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pelc, Leslie A: 2 articles (12/2018 - 11/2010)
2.	Kaufmann, R: 2 articles (03/2003 - 03/2000)
3.	Cera, Enrico Di: 1 article (12/2018)
4.	Pozzi, Nicola: 1 article (12/2018)
5.	Stojanovski, Bosko M: 1 article (12/2018)
6.	Zuo, Xiaobing: 1 article (12/2018)
7.	Bafunno, Valeria: 1 article (11/2014)
8.	Bury, Loredana: 1 article (11/2014)
9.	Caliandro, Rocco: 1 article (11/2014)
10.	Favuzzi, Giovanni: 1 article (11/2014)

Related Diseases

1.	Autolysis 04/01/1991 - "Meizothrombin autolysis could be described by apparent pseudo-first order kinetics and was not eliminated even in the presence of a 100-fold molar excess of DAPA. " 09/01/1982 - "Kinetic studies strongly suggested that the conversion of meizothrombin to meizothrombin-1 was due to ECV and not meizothrombin autolysis. " 11/09/2010 - "A remarkable feature of the structure is that the autolysis loop assumes a helical conformation enabling W148 and W215, located 17 Å apart in meizothrombin desF1, to come within 3.3 Å of each other and completely occlude access to the active site. " 12/15/1997 - "Meizothrombin rapidly loses the fragment 1 domain (F1) by autolysis to become meizothrombin des F1 (mzTBN-F1). " 04/01/1991 - "We conclude that the active site of human meizothrombin can never be completely blocked and autolysis can never be completely prevented even in the presence of saturating concentrations of the active site inhibitor DAPA."
2.	Hemorrhage 11/01/2014 - "Accumulated meizothrombin, however, maintains some fibrinogen-degrading activity, as shown by the formation of FDPs, and this probably explains the patient's mild bleeding phenotype." 10/01/1994 - "Lack of the requisite cleavage of the His271-Thr272 bond in prothrombin Padua I could prevent release of fragment 2 and block the conversion of the intermediate meizothrombin des fragment 1 to alpha-thrombin, providing an explanation of reduced potential for clotting activity and for the observed mild bleeding tendency." 02/02/2011 - "The predominant feedback formation of nonreactive species and high levels of the primarily anticoagulant intermediate meizothrombin (∼40% of total active thrombin species) may provide a mechanism to prevent thrombus propagation downstream of a site of thrombosis or hemorrhage."
3.	Thrombosis (Thrombus) 07/15/2004 - "A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury." 02/02/2011 - "The predominant feedback formation of nonreactive species and high levels of the primarily anticoagulant intermediate meizothrombin (∼40% of total active thrombin species) may provide a mechanism to prevent thrombus propagation downstream of a site of thrombosis or hemorrhage."
4.	Stroke (Strokes) 12/26/2018 - "In addition, we show the properties of a meizothrombin construct analogous to the anticoagulant thrombin mutant W215A/E217A currently in Phase I for the treatment of thrombotic complications and stroke. "
5.	Carotid Artery Injuries 07/15/2004 - "A recombinant murine meizothrombin precursor, prothrombin R157A/R268A, inhibits thrombosis in a model of acute carotid artery injury."

Related Drugs and Biologics

1.	Prothrombin (Factor II)
2.	Thrombin
3.	Anticoagulants
4.	Thrombin Receptors (Thrombin Receptor)
5.	Enzymes
6.	Calcium
7.	Proteins (Proteins, Gene)
8.	Fibrinogen (Factor I)
9.	ecarin