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plastin

Also Known As:

ABP67 protein, S cerevisiae; I-PLASTIN protein, human; I-fimbrin protein, mouse; I-plastin; L-plastin; PLS1 protein, human; PLS3 protein, human; Plastin 3 protein, human; Pls1 protein, mouse; Pls3 protein, mouse; Pls3 protein, rat; SAC6 protein, S cerevisiae; SPBC1778.06c protein, S pombe; T-fimbrin protein, mouse; T-plastin; YDR129C protein, S cerevisiae; fim1 protein, S pombe; fimbrin; fimbrin protein, S pombe; plastin 1 (I isoform) protein, human; plastin 1 (I-isoform) protein, mouse; plastin 3 (T isoform) protein, rat; plastin 3 (T-isoform) protein, mouse; protein p219

Networked: 95 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shinomiya, Hiroto: 6 articles (12/2012 - 06/2003)
2.	Beattie, Christine E: 4 articles (01/2015 - 04/2008)
3.	Bagot, Martine: 4 articles (01/2014 - 02/2008)
4.	Friederich, Evelyne: 4 articles (06/2010 - 04/2005)
5.	Samstag, Yvonne: 3 articles (01/2014 - 01/2007)
6.	Bensussan, Armand: 3 articles (01/2014 - 02/2008)
7.	Wirth, Brunhilde: 3 articles (10/2013 - 04/2008)
8.	Gettemans, Jan: 3 articles (01/2010 - 04/2005)
9.	Delanote, Veerle: 3 articles (01/2010 - 04/2005)
10.	Tang, Yucheng: 3 articles (11/2004 - 09/2002)

Related Diseases

1.	Otitis Media 03/21/2001 - "Passive immunization of chinchillas with serum specific for either LB1 or for LPD-LB1 (f)(2,1,3) prior to challenge with heterologous NTHI isolates (relative to diversity in region three of P5-fimbrin), significantly inhibited the signs and incidence of otitis media (P < or = 0.01) induced by any of the challenge isolates. " 05/01/1994 - "Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A." 08/01/2003 - "Moreover, each was found to be highly efficacious in the reciprocal host system, providing strong support for the continued development and inclusion of both OMP26 and P5 fimbrin-derived peptides as candidate vaccine antigens directed at otitis media caused by nontypeable H. " 05/01/2000 - "While LB1 is based solely on one NTHI adhesin, the latter immunogen, LPD-LB1(f)(2,1,3), was designed to incorporate two NTHI antigens shown to play a role in the pathogenesis of otitis media; lipoprotein D (LPD) and the P5-homologous fimbrin adhesin. "
2.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 04/01/2013 - "Plastin 3 ameliorates spinal muscular atrophy via delayed axon pruning and improves neuromuscular junction functionality." 01/01/2015 - "Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the ∆7 SMA Mouse." 04/15/2014 - "The actin-binding and bundling protein, plastin 3 (PLS3), was identified as a protective modifier of spinal muscular atrophy (SMA) in some patient populations and as a disease modifier in animal models of SMA. " 06/01/2011 - "Plastin 3 expression in discordant spinal muscular atrophy (SMA) siblings." 10/01/2010 - "To investigate the potential association of plastin 3 (PLS3) expression levels in the blood with disease severity in spinal muscular atrophy (SMA). "
3.	Neoplasms (Cancer) 02/05/2010 - "This comparative proteomics study using tissue MALDI-IMS suggested that the IZ is different from the adjacent tumor and normal zones, and that plastin 2 and PRDX 1 may be interface markers specific to ovarian tumors." 07/01/1994 - "Previous studies indicated that, among normal cells, only those of hemopoietic lineages expressed the abundant leukocyte phosphoprotein, L-plastin, and that activation of the L-plastin gene frequently occurred in malignant cells of solid tumors. " 01/01/2014 - "The growth and metastatic potential of tumor cells expressing no L-plastin, phosphorylatable or non-phosphorylatable L-plastin was analyzed in a preclinical mouse model after subcutaneous and intracardial injection of the tumor cells. " 01/01/2012 - "L-plastin is expressed in hematopoietic cell lineages and in many types of cancer cells; the isoform is thus considered to be a useful biomarker for cancer." 02/05/2010 - "Fluorescence microscopy revealed high expression levels of plastin 2 and PRDX 1 along the IZ of ovarian tumors. "
4.	Colonic Neoplasms (Colon Cancer) 04/15/2006 - "L-plastin, a gene that codes for an actin-bundling protein, is upregulated in the metastatic colon cancer cell line SW620, when compared to its premetastatic counterpart SW480. " 02/01/2014 - "Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy." 02/01/2014 - "Recent in vitro and in vivo studies have demonstrated that the plastin genes PLS3 and LCP1 are overexpressed in colon cancer cells and play an important role in tumor cell invasion, adhesion, and migration. " 04/15/2006 - "The leukocyte protein L-plastin induces proliferation, invasion and loss of E-cadherin expression in colon cancer cells." 04/15/2006 - "The association of L-plastin overexpression with an increased rate of proliferation and invasion, and loss of E-cadherin expression in the SW480 colon cancer cell line indicates that L-plastin plays an important mechanistic role in colorectal cancer metastasis (supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html)."
5.	Liver Neoplasms (Liver Cancer) 10/01/2005 - "T-fimbrin was differentially expressed in human liver cancer cell lines. " 10/01/2005 - "In this study, we further investigated the role of T-fimbrin in DNA-damage response using a panel of human liver cancer cell lines and small interfering RNA technology. " 10/01/2005 - "The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents."

Related Drugs and Biologics

1.	Antigens
2.	Peptides
3.	OMPA outer membrane proteins
4.	Cytosine Deaminase
5.	Small Interfering RNA (siRNA)
6.	plastin
7.	Carrier Proteins (Binding Protein)
8.	Proteins (Proteins, Gene)
9.	Actins (F Actin)
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Drug Therapy (Chemotherapy)