octane

06/01/1999 - "In our development of drugs effective against Alzheimer's disease, we have researched a series of aromatic compounds having a characteristic cyclic amine, 1-azabicyclo[3.3.0]octane ring. "
11/08/2012 - "A novel potent and highly selective α4β2 nAChR agonist 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (56, TC-6683, AZD1446) with favorable pharmaceutical properties and in vivo efficacy in animal models has been identified as a potential treatment for cognitive deficits associated with psychiatric or neurological conditions and is currently being progressed to phase 2 clinical trials as a treatment for Alzheimer's disease."
08/01/1998 - "In order to discover a medicine effective against Alzheimer's disease, we synthesized a series of quinoline derivatives having a characteristic 1-azabicyclo[3.3.0]octane amine ring, and performed pharmacological evaluation of them. "
01/01/1999 - "In order to develop drugs effective against Alzheimer's disease, we synthesized a series of aniline derivatives having a characteristic cyclic amine, 1-azabicyclo[3.3.0]octane ring, and evaluated their binding affinity for the central muscarinic cholinergic receptor. "

01/01/2019 - "OCTANE is a general informatics framework that can be helpful for establishing and maintaining a comprehensive database necessary for automating patient-trial matching, which facilitates the successful delivery of personalized cancer care on a routine basis. "
01/01/2022 - "Patients with mCSPC were prospectively recruited at the Princess Margaret Cancer Centre to the OCTANE trial (NCT02906943). "
01/01/2019 - "Using OCTANE, we annotated 5,439 oncology clinical trials (4,438 genomically informed trials) that collectively were associated with 1,453 drugs, 779 genes, and 252 cancer types. "
01/01/2019 - "To illustrate how the framework can be applied at an institution, we describe how we implemented an instance of OCTANE at a large cancer center. "
10/05/2018 - "Their absolute structures (1-3) with a benzoxabicyclo[3.2.1]octane core were determined by spectroscopy, X-ray crystallography, and total synthesis of 1. Compound 1 displays antiproliferative activity against HL-60 cancer cells and the malarial parasite Plasmodium falciparum. "

05/07/2015 - "We have updated the rate constants and thermodynamic parameters for species involved in these reactions into a current chemical kinetic mechanism and also have improved the concentration profiles of main products such as C3H6 and C4H6 in the shock tube pyrolysis of iso-octane. "
03/01/2007 - "Lactate in shock: a high-octane fuel for the heart?"
11/20/2009 - "Validation experiments were conducted for a single-component hydrocarbon fuel (2,2,4-trimethyl-pentane, commonly known as iso-octane) and a gasoline blend in a heated static cell (300 < or = T < or = 600 K) and behind planar shock waves (600 < T < 1100 K) in a shock tube. "
02/09/2023 - "The influence of methanol and butanol on soot formation during the pyrolysis of a toluene primary reference fuel mixture with a research octane number (RON) of 91 (TPRF91) was investigated by conducting shock-tube experiments. "

12/01/2013 - "None of the test products offered protection against n-octane-induced clinical irritation or stratum corneum dehydration. "
12/01/2013 - "One test product significantly aggravated the skin irritation induced by both irritants, and a second one enhanced dehydration induced by n-octane only. "

04/24/2012 - "To estimate nevirapine (NVP) pharmacokinetics and examine its association with rash and/or hepatotoxicity in women starting antiretroviral treatment in the AIDS Clinical Trials Group A5208/OCTANE study in Africa. "
03/01/2015 - "It was introduced to eliminate the use of leaded gasoline and to improve the octane quality because it aids in the complete combustion of fuel by supplying oxygen during the combustion process. "
10/03/2019 - "A case (ART failure) control (nonfailure) study was designed to assess whether linkage of DRMs in pre-ART plasma samples was associated with treatment outcome in the nevirapine/tenofovir/emtricitabine arm of the AIDS Clinical Trials Group A5208/Optimal Combined Therapy After Nevirapine Exposure (OCTANE) Trial 1 among women who had received prior single-dose nevirapine. "
03/03/2021 - "The inclusion of the platelets aids in mitigating permeation of inert hydrocarbons (octane) and toxic chemicals (2-chloroethyl ethyl sulfide, 2-CEES) of dimensions/chemistry similar to prominent vesicant threats while still maintaining high water vapor transport rates (WVTR). "