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9 alpha,11 alpha,15 alpha- trihydroxy- 16- phenoxy- 17,18,19,20- tetranorprosta- 4,5,13- trienoic acid (TPT)

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Also Known As:

TPT; 9 alpha,11 alha,15 alpha-trihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acid; TPTPT; 4,5-Heptadienoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-4-phenoxy-1-butenyl)cyclopentyl)-

Networked: 236 relevant articles (13 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Jian: 4 articles (05/2013 - 08/2002)
2.	Drummond, Daryl C: 3 articles (12/2011 - 07/2006)
3.	Noble, Charles O: 3 articles (12/2011 - 07/2006)
4.	Park, John W: 3 articles (12/2011 - 07/2006)
5.	Errington, R J: 3 articles (11/2011 - 01/2005)
6.	Smith, P J: 3 articles (11/2011 - 01/2005)
7.	Vidaur, Fernando: 3 articles (09/2007 - 11/2005)
8.	Amondarain, José Antonio: 3 articles (09/2007 - 11/2005)
9.	Stewart, Clinton F: 3 articles (01/2007 - 03/2002)
10.	Quesada, Piera: 2 articles (04/2015 - 01/2011)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2008 - "In the treatment study, both eyes of TPT-treated mice demonstrated significant reduction in tumor burden compared with both eyes of mice treated with FS only (59% reduction; P = 0.04). " 01/01/2007 - "These more "matured" vessels facilitated improved tumor TPT penetration (51.2% +/- 4.2%) compared with controls (30.8% +/- 4.7%, P = .004). " 01/15/2011 - "Pharmacokinetic and tumor-response studies, including analyses of ocular and hematopoietic toxicity, revealed that CBP(subcon)/TPT(syst) was more effective and had fewer side effects than TPT(subcon)/CBP(syst). " 01/01/2006 - "Further studies are needed to explore the role of MRP4 in resistance to, toxicity and pharmacokinetics of TPT in cancer patients." 05/01/2005 - "The results of biodistribution studies in S180 tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. "
2.	Arthritis (Polyarthritis) 01/01/2014 - "[Results] After 2 months, the six-minute walk test (6MWT), Western Ontario and McMaster Universities Arthritis Index (WOMAC), and SF-36 testing showed significant improvement in both groups, but the improvement of the TPT group was greater. " 06/01/2008 - "Voix pedis' swelling and arthritis index in XFC, MTX and TPT groups were all obviously improved as compared with the untreated group. " 01/01/2012 - "To observe the effects of tripterygium glycosides tablet (TPT) on swelling degree, arthritis index (AI), pulmonary function, cytokines, the expression of regulatory T cells (Treg), and Foxp3 in rats of adjuvant arthritis. "
3.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2005 - "This study investigates the role of BCRP in resistance of ovarian cancer to TPT treatment. " 03/01/2004 - "A TPT-resistant ovarian cancer cell line A2780/TPT established in this laboratory was used in this study. " 01/01/2015 - "Our findings suggest that the addition of CHEK1 inhibitor increases the response of ovarian cancer cells to TPT. " 01/01/2015 - "When combined with CHEK1 inhibitor, TPT potently and synergistically inhibited the proliferation of HGS ovarian cancer cells. " 01/01/2015 - "Non-HGS ovarian cancer cells were generally more sensitive to TPT treatment compared to HGS ovarian cancer cells. "
4.	Brain Neoplasms (Brain Tumor) 07/01/2006 - "We conclude that the combination of a novel nanoparticle Ls-TPT and CED administration was very effective in treating experimental brain tumors." 01/01/2007 - "In this study, we evaluated a combination of nanoliposomal topotecan (nLs-TPT) and pegylated liposomal doxorubicin (PLD) to enhance efficacy in our brain tumor models, and to establish a CED treatment capable of improving survival from malignant brain tumors. " 08/01/1998 - "camptothecin (CPT) and topotecan (TPT), and chemotherapeutic agents known to be active in treatment of brain tumors, in vitro studies were conducted with human glioma and medulloblastoma cell lines. "
5.	Body Weight (Weight, Body) 01/01/2012 - "The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. " 01/01/2010 - "In this study the effects of maternal exposure to TPT at doses of control (0), 1.875, 3.75, or 7.5 mg/kg body weight/d, po, were examined during gestation and lactation on offspring growth, organ weights, and fertility. " 12/01/2011 - "The body weight of the XFC group was significantly higher than those of the MTX- and TPT-treated groups. " 12/01/2007 - "Body weight was monitored to assess TPT-induced toxicity, and serial blood samples were collected and analyzed via HPLC to assess TPT pharmacokinetics. " 08/01/1991 - "In offspring, little effect of TPT on body weight, pinna detachment, incisor eruption, eye opening, surface righting, cliff avoidance, pivoting and negative geotaxis was found in either the 4 mg/kg or 8 mg/kg groups. "

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4.	irinotecan (Camptosar)
5.	Inflammation Mediators
6.	Ganciclovir (Cytovene)
7.	Uranyl Nitrate
8.	Thymidine Kinase
9.	Probenecid (Benemid)
10.	Cadmium

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Photochemotherapy (Photodynamic Therapy)
4.	Massage (Reflexology)
5.	Transplants (Transplant)