villin

major protein of microvillus cytoskeleton which binds both G & F actin; 95 kDa cytoskeletal component of intestinal brush borders; also binds calcium; GenBank U10070 (quail protein)

Also Known As:

Networked: 268 relevant articles (7 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Hark Kyun: 5 articles (01/2022 - 07/2014)
2.	Park, Jun Won: 5 articles (01/2022 - 07/2014)
3.	Robine, Sylvie: 5 articles (04/2013 - 08/2002)
4.	George, Sudeep P: 4 articles (10/2016 - 04/2008)
5.	Khurana, Seema: 4 articles (10/2016 - 04/2008)
6.	Buer, Jan: 4 articles (03/2016 - 08/2006)
7.	Wang, Hanlin L: 4 articles (08/2014 - 04/2004)
8.	Louvard, Daniel: 4 articles (04/2013 - 08/2002)
9.	Shureiqi, Imad: 3 articles (01/2022 - 04/2014)
10.	Zuo, Xiangsheng: 3 articles (01/2022 - 04/2014)

Related Diseases

1.	Colitis 01/01/2020 - "To identify the mechanism by which SO ameliorates colitis, epithelial cell and innate myeloid cells-specific Atg7-deficient mice (Villin-cre; Atg7f/f and LysM-cre; Atg7f/f mice, respectively) were analyzed. " 01/01/2020 - "SO-mediated inhibition of colitis was observed in Villin-cre; Atg7f/f mice. " 03/01/2016 - "In this study, we established a new mouse model in which the adoptive transfer of naive hemagglutinin (HA)-specific CD4(+)Foxp3(-) T cells into VILLIN-HA transgenic mice leads to severe colitis. " 01/15/2020 - "Through the sequencing of bacterial 16S rRNA gene amplicons, bacteria potentially deleterious to intestinal homeostasis such as Helicobacter japonicum and Bilophila were found to be over-represented in colitis induced Villin-Cre;Gankyrinf/f mice when compared to Gankyrinf/f control mice under the same condition. " 01/01/2020 - "Here we show that mice with inducible conditional knockdown (KD) of Dsc2 in IEC (Villin-CreERT2; Dsc2 fl/fl) exhibited impaired mucosal repair after biopsy-induced colonic wounding and recovery from dextran sulfate sodium-induced colitis. "
2.	Colonic Neoplasms (Colon Cancer) 01/01/1988 - "Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture." 01/01/2017 - "Villin immunohistochemistry is useful in the detection of reverse polarity of MPP of colon cancer." 06/01/2013 - "We analyzed the development of colon cancer in mice that express a constitutive active form of LXRα only in the intestinal epithelium, under the control of villin promoter (iVP16LXRα). " 04/01/2012 - "Villin expression is frequently lost in poorly differentiated colon cancer." 09/01/2001 - "Mucinous BACs are usually TTF nonreactive and CK20 reactive, but nonreactive with villin, which distinguishes them from mucinous colon adenocarcinomas."
3.	Carcinoma (Carcinomatosis) 01/01/2008 - "The stroma-facing surface of the micropapillae was positive for CD10 and villin, confirming the inside-out growth pattern characteristic of micropapillary carcinoma. " 04/01/2006 - "Rb rearrangement due to ectopic Villin promoter activity in neural crest or neural crest stem cells during embryogenesis is most likely responsible for the medullar carcinoma of the thyroid phenotype. " 09/01/2005 - "None of the urothelial carcinomas exhibited CDX2 or villin immunoreactivity; and only two (14%) showed positive staining for AMACR. " 09/01/2002 - "The single urothelial carcinoma with glandular differentiation and all 5 control cases of urothelial carcinoma were CK-7 and CK-20 positive, and villin negative. " 04/01/1988 - "Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines."
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "In addition, tissue samples of colorectal carcinoma and adjacent normal tissues from 45 patients were immunostained for sEH and villin. " 11/01/2019 - "CDX2 and Villin might not be useful as a prognostic factor in advanced stage colorectal carcinoma." 11/01/2019 - "Immunohistochemical technique was used for the localisation of CDX2 and Villin in colorectal cancer tissues. " 11/01/2019 - "Prognostic Value of CDX2 and Villin Expression in Advanced Stage Colorectal Carcinoma." 01/01/2013 - "Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival."
5.	Adenocarcinoma of Lung 09/01/1998 - "Lung adenocarcinomas metastatic to the brain with and without ultrastructural evidence of rootlets: an electron microscopic and immunohistochemical study using cytokeratins 7 and 20 and villin." 04/01/1998 - "In summary, villin positivity is more common in lung adenocarcinoma with rootlets (67%) than those without rootlets (10%). " 04/01/1998 - "The combination of villin, CK 7, and CK 20 is helpful in differentiating metastatic colon adenocarcinoma from lung adenocarcinoma with rootlets." 04/01/1998 - "The reports of villin immunoreactivity in lung adenocarcinoma range from 6% to 68% in studies using various fixations and varied anti-villin antibodies. " 09/01/1998 - "This study examines the ultrastructural morphology and immunohistochemical expression of villin (associated with rootlets), cytokeratin 7 (present in lung adenocarcinomas), and cytokeratin 20 (present in colon adenocarcinomas) in 19 formalin-fixed sequential surgical biopsies of lung adenocarcinomas metastatic to brain as compared to 13 colonic adenocarcinoma metastases. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Cadherins (E-Cadherin)
3.	Cytokines
4.	Autoantibodies
5.	Claudin-2
6.	Interleukin-10 (Interleukin 10)
7.	Occludin
8.	Claudin-1
9.	Interleukin-8 (Interleukin 8)
10.	Transcription Factor 7-Like 2 Protein

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Chemoprevention
3.	Liver Transplantation
4.	Kidney Transplantation
5.	Nephrectomy