villin

major protein of microvillus cytoskeleton which binds both G & F actin; 95 kDa cytoskeletal component of intestinal brush borders; also binds calcium; GenBank U10070 (quail protein)

Also Known As:

Networked: 170 relevant articles (3 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Robine, Sylvie: 5 articles (04/2013 - 08/2002)
2.	Wang, Hanlin L: 4 articles (08/2014 - 04/2004)
3.	Louvard, Daniel: 4 articles (04/2013 - 08/2002)
4.	Kucherlapati, Melanie H: 3 articles (12/2015 - 04/2006)
5.	Park, Jun Won: 3 articles (11/2015 - 07/2014)
6.	Kim, Hark Kyun: 3 articles (11/2015 - 07/2014)
7.	Mishra, Jayshree: 3 articles (11/2013 - 10/2007)
8.	Kumar, Narendra: 3 articles (11/2013 - 10/2007)
9.	Tanaka, Harunari: 3 articles (01/2013 - 01/2005)
10.	Merchant, Juanita L: 3 articles (09/2012 - 02/2005)

Related Diseases

1.	Adenocarcinoma 09/01/1998 - "Lung adenocarcinomas metastatic to the brain with and without ultrastructural evidence of rootlets: an electron microscopic and immunohistochemical study using cytokeratins 7 and 20 and villin." 01/01/1988 - "Villin, a specific marker for some epithelia specialized in transport, to study the differentiation of intestinal and kidney cells in vivo and in a human colon adenocarcinoma line HT29 in culture." 11/01/2015 - "They were generated from gastric adenocarcinomas that formed in a Villin-cre, Smad4(F/F) , Trp53(F/F) , Cdh1(F/wt) mouse and a Pdx1-cre, Trp53(F/F) , Cdh1(F/F) mouse, respectively. " 01/01/2014 - "Pathology of the resected prostatic chips revealed an invasive adenocarcinoma with intestinal-type differentiation that stained positive for CK7, CK20, and villin, but negative for PSA, PSAP, uroplakin, and CDX-2. " 02/01/2013 - "This case suggests brush border immunoreactivity of villin is possible in some cases of pulmonary enteric adenocarcinomas. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2013 - "Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival." 10/15/2001 - "Immunocytochemical detection of bone marrow micrometastases in colorectal carcinoma patients, using a monoclonal antibody to villin." 01/15/1990 - "Presence of villin, a tissue-specific cytoskeletal protein, in sera of patients and an initial clinical evaluation of its value for the diagnosis and follow-up of colorectal cancers." 01/01/2008 - "KLF5 expression was examined in intestinal tumors derived from transgenic mice expressing KRAS(V12G) under villin promoter and in human colorectal cancers with mutated KRAS. " 09/01/2005 - "These results demonstrate that CDX2 and villin are of diagnostic value in aiding in the distinction between primary adenocarcinoma of the bladder and secondary colorectal carcinoma. "
3.	Inflammation 04/19/2013 - "purpurea extracts were able to significantly increase the expression of markers of epithelial integrity such as MUC-2, MUC-3 and villin, thus revealing an improvement in the altered colonic permeability that characterizes colonic inflammation. " 12/01/2013 - "Consistent with these defective immune responses, Atg16l1(f/f) × Villin-cre mice had increased inflammation and systemic translocation of bacteria compared with control mice. " 01/01/2008 - "In addition, proliferation (Ki67), differentiation (villin, cytokeratins 7 and 20) and inflammation (COX-2) were investigated by immunohistochemistry (IHC). " 08/01/2006 - "In contrast, adoptive transfer of naive transgenic CD8+ T cells from CL4-TCR transgenic mice into VILLIN-HA transgenic mice induced severe intestinal inflammation with poor clinical course of disease. " 01/01/2012 - "Lgr5, Villin-promoter, TFF2-mRNA and Mist have recently been identified as gastric stem/progenitor cell markers; their identification enriched our understanding on the gastric stem cell pathobiology during chronic inflammation and metaplasia. "
4.	Neoplasms (Cancer) 08/01/2002 - "This study presents transgenic mice that express K-ras(V12G), the most frequent oncogenic mutation in human tumors, under control of the murine villin promoter in epithelial cells of the large and small intestine. " 04/01/2015 - "On immunohistochemistry the tumor was positive for villin and CK20 and negative for CK7, CDX2, and thyroid transcription factor-1. " 01/01/2015 - "The results showed that villin was negative in all breast cancers with a specificity of 100%, and positive in all ICCs with a sensitivity of 100%. " 07/01/2014 - "mir-17-92 TG/TG mice overexpressing the mir-17-92 cluster under the villin promoter developed spontaneous benign tumors in the intestinal tract (log-rank P for tumor-free survival = 0.069). " 03/01/2012 - "Villin-Cre(+);Klf4(fl/fl) have greater susceptibility to chemical-induced gastric carcinogenesis and increased rates of gastric tumor progression than control mice."
5.	Metaplasia 02/01/1999 - "In this study, the ability to identify intestinal metaplastic cells by using this distinct villin staining pattern was examined in endoscopic esophageal brushings from patients with confirmed Barrett's metaplasia. " 03/28/1996 - "Mapping studies failed to reveal any correlation among histologic evidence of metaplasia, dysplasia and villin expression and confirmed the multifocal heterogeneity of villin expression in BE. " 01/01/2012 - "Expression of CDX2 and villin in gastric cardiac intestinal metaplasia and the relation with gastric cardiac carcinogenesis." 11/15/2007 - "We further show that Brm is required for villin expression, a definitive marker of intestinal metaplasia and differentiation. " 12/01/2006 - "All intestinal metaplasia samples (55) were positive for CDX2 and MUC2 and 32 of 55 for villin. "

Related Drugs and Biologics

1.	Transcription Factor 7-Like 2 Protein
2.	Cyclin A2
3.	Cyclin B1
4.	Adenocarcinoma of lung
5.	Keratins (Keratin)
6.	Keratin-20 (Cytokeratin 20)
7.	Keratin-7 (Cytokeratin 7)
8.	Paraffin
9.	Dextrans (Dextran)
10.	sodium sulfate (sodium bisulfate)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Intraperitoneal Injections
3.	Hepatectomy
4.	Oral Administration