butopamine

differs from DOBUTAMINE in location of only one hydroxyl group, but is no longer a catecholamine; structure given in first source

Also Known As:

LY 131126; p-hydroxy-alpha-(((-3-(p-hydroxyphenyl)-1-methylpropyl)amino)methyl)benzyl alcohol; Benzenemethanol, 4-hydroxy-alpha-(((3-(4-hydroxyphenyl)-1-methylpropyl)amino)methyl)-, (R-(R*,R*))-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
- Alcohols: 595
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - 2-Hydroxyphenethylamine: 1
        butopamine: 1

Related Diseases

1.	Ventricular Premature Complexes (Premature Ventricular Contraction) 09/01/1980 - "Although mean premature ventricular contractions per minute did not change, two patients experienced a substantial increase in ventricular ectopy at 0.10 and 0.12 mcg/kg/min. Butopamine induces a positive inotropic response in patients with congestive heart failure but for equal increments in cardiac output, butopamine increases heart rate more than dobutamine."
2.	Heart Failure 09/01/1980 - "We gave butopamine intravenously to eight patients with congestive heart failure using a progressive dose-response protocol ranging from 0.02 to 0.17 mcg/kg/min. The mean cardiac index and stroke volume index increased at doses greater than or equal to 0.06 mcg/kg/min; there was also an increase in heart rate at greater than or equal to 0.06 mcg/kg/min. At greater than or equal to 0.08 mcg/kg/min the augmented stroke volume tended to plateau so that additional increases in the cardiac index were secondary to the elevated heart rate. " 09/01/1980 - "Hemodynamic effects of intravenous butopamine in congestive heart failure." 09/01/1980 - "Although mean premature ventricular contractions per minute did not change, two patients experienced a substantial increase in ventricular ectopy at 0.10 and 0.12 mcg/kg/min. Butopamine induces a positive inotropic response in patients with congestive heart failure but for equal increments in cardiac output, butopamine increases heart rate more than dobutamine."

Related Drugs and Biologics

1.	Dobutamine