3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one

01/01/2017 - "In the neoadjuvant population, a large trial demonstrated a significant increase in urolithin A and a non-significant reduction in 8-hydroxy-2-deoxyguanosine, a marker of oxidation in prostate cancer tissue, on the pomegranate arm vs the placebo arm. "
11/01/2016 - "In this study, the suppressing effects of methylated urolithin A (mUA) on cell viability in human prostate cancer DU145 cells was investigated. "
06/01/2020 - "Urolithin A induces prostate cancer cell death in p53-dependent and in p53-independent manner."
04/01/2016 - "Urolithin A causes p21 up-regulation in prostate cancer cells."
01/01/2019 - "The Activity of Urolithin A and M4 Valerolactone, Colonic Microbiota Metabolites of Polyphenols, in a Prostate Cancer In Vitro Model."

11/01/2017 - "Urolithin A was inversely associated with BMI (β ± SE: -0.004 ± 0.002; P = 0.02) and with 5% lower odds of obesity in models not adjusted for total energy expenditure (TEE; OR: 0.95; 95% CI: 0.91, 0.99; P = 0.02). "
02/01/2023 - "Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation."
01/01/2020 - "In this study, we investigated the ability of both urolithin A (Uro-A) and urolithin B (Uro-B) to attenuate obesity and associated symptoms in a high-fat diet-induced obesity model in rats. "
01/01/2020 - "Here, we report that urolithin A (UA), a gut-microflora-derived metabolite of pomegranate ellagitannins (ETs), prevents diet-induced obesity and metabolic dysfunctions in mice without causing adverse effects. "
11/01/2017 - "Conclusions: Although associations were weak, resveratrol and urolithin A were inversely associated with obesity. "

07/24/2023 - "In this study, we demonstrate that treatment with the microbial metabolite urolithin A (UroA) attenuates CDI-induced adverse effects on the colon epithelium in a preclinical model of CDI-induced colitis. "
01/01/2022 - "Recently, we demonstrated that the microbial metabolite Urolithin A (UroA) mitigates colitis through its gut barrier protective and anti-inflammatory activities in an AhR-dependent manner. "
08/01/2010 - "Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism."
01/01/2022 - "Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis."
10/09/2023 - "In fact, urolithin A (UroA), a metabolite transformed from ellagic acid by the gut microbiota, was found to alleviate colitis and enhance gut barrier function in an IL22-dependent manner. "

12/11/2019 - "Our results suggested that the protective effects of PPPs in HFD-induced metabolic inflammation can be due to the recovery of colonic tissue damage and the regulation of gut microbiota and that urolithin A is the major component that contributes to the in vivo effects of PPPs."
01/01/2023 - "In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting the activation of microglia and release of inflammation factors. "
12/01/2021 - "Urolithin A suppresses glucolipotoxicity-induced ER stress and TXNIP/NLRP3/IL-1β inflammation signal in pancreatic β cells by regulating AMPK and autophagy."
08/01/2010 - "Our objectives were to evaluate the effects of pomegranate intake and its main microbiota-derived metabolite urolithin-A (UROA) on colon inflammation and to assess whether UROA is the main anti-inflammatory compound. "
01/01/2022 - "Urolithin A induces protective autophagy to alleviate inflammation, oxidative stress, and endoplasmic reticulum stress in pediatric pneumonia."

10/23/2021 - "Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease."
08/03/2021 - "Effects of Urolithin A on Mitochondrial Parameters in a Cellular Model of Early Alzheimer Disease."
01/01/2023 - "Urolithin A exhibits a neuroprotective effect against Alzheimer's disease by inhibiting DYRK1A activity."
01/01/2023 - "Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease."
01/01/2022 - "A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer's Disease."