HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

4-chloro-3-hydroxyanthranilic acid

metabolite of 6-chlorotryptophan; inhibitor of 3-hydroxyanthranilic acid oxidase

Also Known As:

4-Cl-3-hana; 4-chloro-3-hydroxyanthranilate; Benzoic acid, 2-amino-4-chloro-3-hydroxy-

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Blight, A R: 1 article (09/2014)
2.	Gay, E A: 1 article (09/2014)
3.	Heyes, M P: 1 article (09/2014)
4.	Yates, J R: 1 article (09/2014)
5.	Blight, Andrew R: 1 article (06/2006)
6.	Heyes, Melvyn P: 1 article (06/2006)
7.	Yates, Jennifer R: 1 article (06/2006)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/1996 - "4-Chloro-3-hydroxyanthranilate is a potent inhibitor of QUIN production by macrophages and reduces QUIN accumulations in spinal cord injury. " 09/01/2014 - "Effects of methylprednisolone and 4-chloro-3-hydroxyanthranilic acid in experimental spinal cord injury in the guinea pig appear to be mediated by different and potentially complementary mechanisms." 06/01/2006 - "4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury." 09/01/2014 - "Blinded, placebo-controlled, parallel treatment group studies of the effects of methylprednisolone (MP) or 4-chloro-3-hydroxyanthranilate (4-Cl-3-HAA) on behavioral outcome and quinolinic acid tissue levels from experimental thoracic spinal cord injury in adult guinea pigs. "
2.	Transient Ischemic Attack 01/01/1996 - "4-chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil."
3.	Brain Diseases (Brain Disorder) 01/01/1994 - "The results suggest that QUIN synthesis inhibitors such as 4-chloro-3-hydroxyanthranilic acid may become of value in brain diseases that are caused by hyperphysiological quantities of QUIN."

Related Drugs and Biologics

1.	Quinolinic Acid
2.	Methylprednisolone