hydrogen selenide

06/17/2023 - "Selenium compounds have been shown to have chemotherapeutic effects against cancer, and their anticancer mechanism is thought to be related to the formation of their metabolites, including hydrogen selenide (H2Se), which is a highly reactive and reducing molecule. "
01/01/2019 - "However, the anti-cancer mechanism of selenium is not fully understood, and the role of hydrogen selenide (H2Se), which is a common metabolite of dietary selenium compounds, has not been elucidated due to the lack of detection methods. "
12/04/2018 - "Hence, considering the main metabolite of Na2SeO3 in the metabolic process to be hydrogen selenide (H2Se) and also that it can be converted to superoxide anion (O2˙-) instantaneously in the presence of oxygen, a dual-ratiometric fluorescence imaging system for simultaneous monitoring of the changes of H2Se and O2˙- induced by Na2SeO3-guided tumor cell apoptosis under hypoxic conditions was constructed. "
01/01/2018 - "Previous studies proposed that sodium selenite (Na2SeO3) was reduced to hydrogen selenide (H2Se) and that H2Se subsequently reacted with oxygen to generate superoxide anion (O2•-), resulting in tumor cell oxidative stress and apoptosis. "
01/01/2001 - "We review recent data that support a potential antiangiogenic effect of selenium (Se) in the chemoprevention of cancer and data that contrast two pools of Se metabolites, namely, methylselenol vs. hydrogen selenide, that differentially affect proteins and cellular processes crucial to tumor angiogenesis regulation. "

11/01/1986 - "Hydrogen selenide poisoning: an illustrative case with review of the literature."
05/29/1958 - "[Acute poisoning by hydrogen selenide vapors]."
12/22/1950 - "[A case of hydrogen selenide poisoning]."

01/01/2019 - "Hydrogen selenide (H2Se), a central metabolite of Se supplements, displays critical biological functions in many physiological and pathological processes. "
02/01/2016 - "Hydrogen selenide (H2Se), a highly reactive Se species, is an important selenium metabolism intermediate involved in many physiological and pathological processes. "

10/01/2002 - "To explore potential molecular targets for mediating the chemopreventive activity, we contrasted the effects of methylseleninic acid (MSeA), a novel precursor of methylselenol, versus sodium selenite, a representative of the hydrogen selenide metabolite pool, on apoptosis execution, cell cycle distribution, and selected protein kinases in DU145 human prostate cancer cells. "

03/01/2021 - "Hydrogen selenide, a vital metabolite of sodium selenite, uncouples the sulfilimine bond and promotes the reversal of liver fibrosis."
03/01/2021 - "Herein, hydrogen selenide, a major metabolite of Na2SeO3, was tested to uncouple the sulfilimine bond in collagen IV, the biomarker of liver fibrosis. "