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15-ketoprostaglandin E2

metabolite of PGE2; RN given refers to (5Z,11alpha,13E)-isomer
Also Known As:
15-keto-PGE2; 15-keto-prostaglandin E2; 15-ketoprostaglandin E2, (11alpha)-isomer; 15-oxo-PGE2; 9,15-dioxo-11-hydroxyprosta-5,13-dienoic acid
Networked: 14 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Han, Chang: 3 articles (01/2017 - 07/2013)
2. Wu, Tong: 3 articles (01/2017 - 07/2013)
3. Aldrovandi, Maceler: 2 articles (11/2020 - 01/2019)
4. Bielska, Ewa: 2 articles (11/2020 - 01/2019)
5. Evans, Robert J: 2 articles (11/2020 - 01/2019)
6. Johnston, Simon A: 2 articles (11/2020 - 01/2019)
7. Krause, Henry M: 2 articles (11/2020 - 01/2019)
8. Loynes, Catherine A: 2 articles (11/2020 - 01/2019)
9. May, Robin C: 2 articles (11/2020 - 01/2019)
10. Needs, Sarah: 2 articles (11/2020 - 01/2019)

Related Diseases

1. Cholangiocarcinoma
2. Hepatocellular Carcinoma (Hepatoma)
3. Inflammation (Inflammations)
01/01/2020 - "Here, using cell-based experiments and in silico simulations, we show that PGE2-activated EP4 receptor-mediated signaling may evoke the primary initiating reaction of the cells, which would take over the 15-keto-PGE2-activated EP2 receptor-mediated signaling after PGE2 is metabolized to 15-keto-PGE2 The present results shed light on new aspects of 15-keto-PGE2, which may have important roles in passing on activities to EP2 receptors from PGE2-stimulated EP4 receptors as a "switched agonist." This novel mechanism may be significant for gradually terminating PGE2-evoked inflammation and/or maintaining homeostasis of colorectal tissues/cells functions."
01/01/2020 - "After sufficient inflammation has been evoked by PGE2, it is metabolized to 15-keto-PGE2 Thus, 15-keto-PGE2 has long been considered an inactive metabolite of PGE2 However, it may have an additional role as a biased and/or partial agonist capable of taking over the actions of PGE2 to gradually terminate reactions. "
01/01/2019 - "report that Treg cells catabolize PGE2 into 15-keto-PGE2, a T cell-inhibitory metabolite, and that this mechanism controls inflammation in adipose tissue."
01/01/2017 - "Therefore, induction of 15-PGDH expression or utilization of 15-keto-PGE2 analogue may have therapeutic benefits for the treatment of endotoxin-associated liver inflammation/injury."
10/20/2023 - "In mice with non-alcoholic steatohepatitis (NASH) induced by a prolonged HFHSD, 15-keto-PGE2 treatment significantly decreased liver inflammation, lowered serum levels of alanine transaminase (ALT) and aspartate transferase (AST), and inhibited macrophage infiltration. "
4. Neoplasms (Cancer)
5. Infections

Related Drugs and Biologics

1. Peroxisome Proliferator-Activated Receptors (PPAR)
2. Dinoprostone (PGE2)
3. 15-hydroxyprostaglandin dehydrogenase
4. Ligands
5. PPAR gamma
6. Proteins (Proteins, Gene)
7. Eicosanoids
8. 6-Ketoprostaglandin F1 alpha (6 Ketoprostaglandin F1 alpha)
9. Transferases
10. Thromboxane B2