trichlorosucrose (sucralose)

sweetness intensity roughly 600 times that of sucrose and is nonnutritive and noncaloric; largely unabsorbed in the gastrointestinal tract

Also Known As:

sucralose; Splenda; 1',4',6'-trichloro-1',4,6'-trideoxygalactosucrose; 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl-4-chloro-4-deoxy-alpha-D-galactopyranoside; trichlorogalacto-sucrose; trichlorogalactosucrose; alpha-D-Galactopyranoside, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-

Networked: 141 relevant articles (3 outcomes, 35 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Polysaccharides: 15383
  - Oligosaccharides: 3566
    - Disaccharides: 990
      - Sucrose: 7214
        trichlorosucrose: 141
- Sugars: 11126
  - Disaccharides: 990
    - Sucrose: 7214
      - trichlorosucrose: 141

Experts

1.	Qin, Xiaofa: 9 articles (10/2021 - 09/2011)
2.	Anderson, G Harvey: 5 articles (09/2016 - 06/2007)
3.	Liu, Yuanli: 4 articles (10/2021 - 01/2016)
4.	Wang, Xiuhong: 4 articles (10/2021 - 01/2016)
5.	García-Viguera, Cristina: 4 articles (09/2021 - 01/2020)
6.	Patel, Barkha P: 4 articles (01/2020 - 11/2011)
7.	Thomas, Scott G: 4 articles (09/2016 - 06/2007)
8.	Bellissimo, Nick: 4 articles (02/2015 - 06/2007)
9.	Jiang, Mingshan: 3 articles (10/2021 - 01/2016)
10.	Agulló, Vicente: 3 articles (07/2021 - 01/2020)

Related Diseases

1.	Weight Gain 10/19/2021 - "Our results suggest that sucralose consumption promotes different outcomes in relation to weight gain when combined with different diets, which may explain the controversial data in previous studies, and can be considered in future clinical research aimed at clarifying the impact of NNS consumption on human health." 01/01/2020 - "However, several studies link sucralose consumption to weight gain and metabolic derangements, although data are still contradictory. " 10/19/2021 - "We observed that sucralose supplementation reduced weight gain in HFD-fed mice but did not change weight gain in mice fed with normal diet. " 01/01/2018 - "Our results show that frequent intake of commercial SG decreases energy intake, adiposity, and weight gain in male animals, while increasing the expression of pJAK2 and pSTAT3 in the brain, whereas sucralose increases weight gain and pJAK2 expression in females. " 01/01/2000 - "Food consumption and weight gain in the F(0) and F(1) generations were depressed in all sucralose groups before mating and in all four litters prior to weaning. "
2.	Glucose Intolerance 01/01/2022 - "Sucralose consumption ameliorates high-fat diet-induced glucose intolerance and liver weight gain in mice." 01/01/2017 - "OFS, but not sucralose, reduced body weight gain and decreased intestinal permeability, but not glucose intolerance. " 12/01/2016 - "In flies, chronic sweet/energy imbalance promoted hyperactivity, insomnia, glucose intolerance, enhanced sweet taste perception, and a sustained increase in food and calories consumed, effects that are reversed upon sucralose removal. " 06/20/2023 - "In addition, we found that administration of extracellular signal-regulated kinase (ERK)-1/2 inhibitor reversed the effects of sucralose on glucose intolerance and insulin resistance in mice. " 02/01/2023 - "Compared with the sucrose group, mice consuming sucralose showed much lower fat accumulation, hyperlipidaemia, liver steatosis, and glucose intolerance. "
3.	Glucose Metabolism Disorders 12/13/2018 - "Sucralose (0.4 g L-1) was administered to mice to induce glucose metabolic disorders. " 12/13/2018 - "Low intake of digestible carbohydrates ameliorates the duodenal absorption of carbohydrates in mice with glucose metabolic disorders induced by sucralose."
4.	Hyperinsulinism (Hyperinsulinemia) 10/01/2016 - "There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs - including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol+aspartame - have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or - in many cases - even to calorically-sweetened foods or liquids. "
5.	Obesity 01/01/2021 - "The objective of this study was to investigate the effects of lower doses of sucralose on fecal microbiota in obesity. " 01/01/2013 - "Some nutritional aspects for sucralose in obesity and diabetes are also presented. " 11/01/2017 - "The results indicate the presence of a significant CPIR in a subset of individuals with overweight or obesity after oral exposure to sucralose, especially when present in solid food form. " 01/01/2022 - "In this study, we studied the effect of sucralose consumption on glucose homeostasis in a model of obesity. " 01/01/2021 - "Obesity and Sex-Related Associations With Differential Effects of Sucralose vs Sucrose on Appetite and Reward Processing: A Randomized Crossover Trial."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Aspartame (NutraSweet)
3.	Saccharin
4.	acetosulfame (acesulfame K)
5.	Glucagon-Like Peptide 1 (GLP 1)
6.	Carbohydrates
7.	Sweetening Agents (Sweeteners)
8.	Sucrose (Saccharose)
9.	trichlorosucrose (sucralose)
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Therapeutics
2.	Glycemic Control
3.	Caloric Restriction
4.	Oral Administration