12-hydroxy-5,8,10,14,17-eicospentaenoic acid

RN given refers to cpd without isomeric designation

Also Known As:

12-HEP; 12-hydroxy-5,8,10,14,17-eicospentaenoic acid, (E,Z,Z,Z,Z)-isomer; 12-hydroxyeicosapentaenoic acid; 5,8,10,14,17-Eicosapentaenoic acid, 12-hydroxy-

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Abe, Yuichi: 2 articles (01/2021 - 01/2021)
2.	Adachi, Jun: 2 articles (01/2021 - 01/2021)
3.	Hirata, So-Ichiro: 2 articles (01/2021 - 01/2021)
4.	Hosomi, Koji: 2 articles (01/2021 - 01/2021)
5.	Isoyama, Junko: 2 articles (01/2021 - 01/2021)
6.	Kunisawa, Jun: 2 articles (01/2021 - 01/2021)
7.	Morimoto, Sakiko: 2 articles (01/2021 - 01/2021)
8.	Nagatake, Takahiro: 2 articles (01/2021 - 01/2021)
9.	Node, Eri: 2 articles (01/2021 - 01/2021)
10.	Saika, Azusa: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Atherosclerosis 01/01/2021 - "12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice."
2.	Necrosis 04/01/2016 - "On the other hand, in addition to 12-HETE, 15-HETE and 12-hydroxyeicosapentaenoic acid (HEPE) were higher and omega-3/omega-6 polyunsaturated fatty acids ratios were lower in the ND mice at 24 hr. These results of metabolomics indicated that less pro-inflammatory state was seen in HFD mice than in ND mice at 24 hr. Finally, to confirm whether the observed decrease in phosphorylated p38 MAPK could attenuate TA-induced hepatocellular necrosis, we showed that SB203580 hydrochloride, an inhibitor of p38 MAPK, partially attenuated TA-induced hepatic necrosis in ND mice. "
3.	Contact Dermatitis (Eczema, Contact) 01/01/2021 - "ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α."

Related Drugs and Biologics

1.	p38 Mitogen-Activated Protein Kinases
2.	Retinoid X Receptors (Retinoid X Receptor)
3.	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
4.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
5.	Fatty Acids (Saturated Fatty Acids)
6.	SB 203580
7.	15-hydroxy-5,8,11,13-eicosatetraenoic acid