oltipraz

10/15/1991 - "Oltipraz afforded complete protection against both AFB1-induced hepatocellular neoplasms. "
02/01/2010 - "Comprehensive studies indicate that oltipraz exerts cancer chemopreventive effects. "
12/01/2003 - "Dose-response studies were undertaken to characterize the cancer chemopreventive activities of several dithiolethiones that are at least as active as oltipraz as inducers. "
10/01/2002 - "Several preclinical studies indicated that Oltipraz appears to be one of the most potent cancer chemopreventive agents. "
01/01/2001 - "These data coupled with their broad anti-tumor specificity support the use of D3T and oltipraz as cancer-preventive agents in clinical trials."

09/15/2004 - "Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis."
12/01/2002 - "Comprehensive mechanistic and phase IIa clinical studies supported the notion that oltipraz exerts chemopreventive effects against chemical carcinogenesis. "
05/29/2000 - "The results of the present study suggest that oltipraz exerts organ-dependent modifying effects on BOP-induced carcinogenesis in hamsters when given in the initiation stage."
07/01/1998 - "[Studies on inhibition of human lung carcinogenesis in early stage by oltipraz and its effects on some gene expression and regulation]."
06/01/1991 - "The results of this study indicate that dietary oltipraz inhibits intestinal carcinogenesis."

05/01/2011 - "Twenty-four weeks of oltipraz treatment showed no significant differences in the proportions of patients showing an improvement in histological outcomes, including Ishak fibrosis score. "
10/01/2019 - "This study establishes a promising approach for AKI and fibrosis treatment with PLGA-Oltipraz NPs. "
09/01/2023 - "We aimed to examine the oral and topical effect of Oltipraz (OPZ) on fibrosis and healing after urethra injury in a rat model. "
05/01/2006 - "Improved liver function by oltipraz in cirrhotic rats was proved by liver microscopy; livers are free of significant fibrosis, although evidence of bridging necrosis is still present in many rats."
10/01/2019 - "Size and temporal-dependent efficacy of oltipraz-loaded PLGA nanoparticles for treatment of acute kidney injury and fibrosis."

08/01/2006 - "The data from this study show that oltipraz is an effective agent for lung cancer prevention, when it is delivered directly to the target tissue as aerosolized particulates."
08/01/2006 - "This study explored the efficacy of oltipraz, a dithiolthione to prevent lung cancer by delivering it directly to the lung as inhaled particulates to obtain maximum efficacy with no toxicity. "
10/01/2002 - "During a clinical trial designed to monitor eventual Oltipraz toxicity in high-risk population for development of lung cancer, we performed companion studies related to cell proliferation. "
01/01/1990 - "Some of the most interesting positive results observed include 4-hydroxyphenyl retinamide plus tamoxifen in breast cancer, piroxicam in colon cancer, dimethylfluoroornithine in breast and bladder cancer, oltipraz in lung cancer, dehydroepiandrosterone in colon cancer, and molybdate in bladder cancer. "

05/01/2006 - "Improved liver function by oltipraz in cirrhotic rats was proved by liver microscopy; livers are free of significant fibrosis, although evidence of bridging necrosis is still present in many rats."
03/01/2002 - "Histopathologically, enlarged hepatocytes with large nuclei, focal necrosis, pigment granule-laden Kupffer cells and hypertrophy of renal tubule cells were observed in both groups, but the severity of these changes was greater in the oltipraz group. "
10/20/2020 - "MTB-induced reactive oxygen species production, mitochondrial depolarization and programmed necrosis were attenuated by oltipraz in macrophages. "
10/01/2019 - "Mice with AKI treated with PLGA-Oltipraz NPs exhibited significantly reduced tubular necrosis, less collagen deposition, and better renal function at the initial phase as well as improved renal fibrosis at the recovery phase. "
01/01/2014 - "Higher bile flow and glutathione secretion rates were observed in unoperated mice treated with oltipraz than in control mice, suggesting that liver necrosis in oltipraz-treated BDL mice may be related partially to increased bile-acid independent flow and biliary pressure. "