4-nitroanisole O-demethylase

contains cytochrome P-450, cytochrome b5, NADPH-cytochrome P-450 reductase & NADH-cytochrome b5 reductase

Also Known As:

p-nitroanisole O-demethylase; p-nitroanisole O-demethylating system; p-nitroanisole O-demethylation system; para-nitroanisole O-demethylase

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - O-Demethylating Oxidoreductases: 3
      - 4-nitroanisole O-demethylase: 5

Related Diseases

1.	Seizures (Absence Seizure) 01/01/1994 - "No significant associations were observed between the susceptibility to the tonic-clonic seizures in Mongolian gerbils and the drug-metabolizing enzymatic activities of p-nitroanisole O-demethylase, aminopyrine demethylase and benzo[a]pyrene-3-monooxygenase. "
2.	Infections 04/01/1990 - "to the infested rat for the entire course of the infection (40 days) positively affects the parameters reflecting the integrity of the liver cell (serum glutamate-pyruvate, GPT and glutamate-oxaloacetate, GOT, transaminases) and the detoxifying capacity of the liver (cytochrome P-450, cytochrome b5, cytochrome P-450-dependent p-nitroanisole O-demethylase and aniline hydroxylase activities, and the p-nitrophenol glucuronidation) and greatly reduces the lipid peroxidative phenomen in membranes from whole liver (tissue malonic dialdehyde content) and in membranes of the microsomal fraction (conjugated diene absorption). "
3.	Hypertrophy 02/01/1985 - "TCPOBOP induced liver hyperplasia and hypertrophy and increased p-nitroanisole-O-demethylase and aminopyrine-N-demethylase more than PB. "
4.	Hyperplasia 02/01/1985 - "TCPOBOP induced liver hyperplasia and hypertrophy and increased p-nitroanisole-O-demethylase and aminopyrine-N-demethylase more than PB. "
5.	Hepatomegaly 03/01/1996 - "In the case of both pesticides the early effects observed consisted of hepatomegaly accompanied by an increase in the p-nitroanisole O-demethylase activity and hepatocyte proliferation. "

Related Drugs and Biologics

1.	Oxaloacetic Acid (Oxalacetic Acid)
2.	Pyruvic Acid (Pyruvate)
3.	Glutamic Acid (Glutamate)
4.	Cytochromes b5 (Cytochrome b5)
5.	Lipids
6.	Mixed Function Oxygenases (Monooxygenases)
7.	Cytochrome P-450 Enzyme System (Cytochrome P450)
8.	Benzo(a)pyrene
9.	Aniline Hydroxylase
10.	Transaminases (Aminotransferases)