fiacitabine (FIAC)

anti-herpes virus agent which also inhibits growth of certain human tumor cell lines in vitro.

Also Known As:

FIAC; 1-(2-fluoro-2-deoxy-beta-D-arabinofuranosyl)-5-iodocytosine; 2'-deoxy-2'-fluoro-beta-arabinofuranosyl-5-iodocytosine; 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine; 2'-fluoro-5-iodo-aracytosine; 2(1H)-pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-; 4-amino-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodo-2(1H)-pyrimidinone,; fiacitabine monohydrochloride; fiacitabine monohydrochloride, 2-(14)C-labeled; fiacitabine, (alpha-D)-isomer

Networked: 16 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Pain (Aches) 09/01/1986 - "The median time to the appearance of the last new lesion was shorter in patients who received FIAC relative to those who received ara-A (two versus five days, respectively; P less than .001) FIAC also reduced pain and accelerated initial crusting within 72 hr in a significantly greater proportion of patients when compared with ara-A (P = .004 and P = .0009, respectively). "
2.	Herpes Simplex 11/01/1984 - "Metabolic competition studies of 2'-fluoro-5-iodo-1-beta-d-arabinofuranosylcytosine in vero cells and herpes simplex type 1-infected vero cells."
3.	Infectious Encephalitis 01/01/1984 - "The 125I labeled analog of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) has been prepared for studies on the imaging of herpes simplex virus (HSV) encephalitis infections in animals. "
4.	Infections 09/01/1986 - "Thus FIAC is therapeutically superior to ara-A for the treatment of varicella-zoster virus infections in immunosuppressed subjects." 09/01/1986 - "For examination of the clinical efficacy of FIAC, a randomized, double-blind study of FIAC versus adenine arabinoside (ara-A) was conducted in 34 immunosuppressed individuals with varicella-zoster virus infections. " 03/01/1982 - "With cell homogenates of noninfected Vero cells, thymidine (TdR) was phosphorylated about fifty and twenty times more efficiently than FIAC and ara-C, while infection of Vero cells with Herpes Simplex Virus Type 1 (HSV-1) resulted in a 23-fold increase of TdR- and a 1270-fold increase of FIAC phosphorylation. " 03/01/1990 - "The treatment of woodchuck hepatitis virus infections with 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine (FIAC) and 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil (FMAU), given intraperitoneally, caused complete and permanent decrease of serum virus endogenous DNA polymerase and viral DNA in all treated woodchucks but was associated with severe toxicity. " 10/01/1985 - "In a herpes type 2 infection model in mice, DHPG, and FMAU were active at 5 mg/kg, whereas acyclovir and FIAC showed no statistically significant effect at 80 mg/kg. In a herpes type 1 encephalitis model, DHPG and FMAU were active at doses less than 10 mg/kg, with FMAU being about 4 times more potent than DHPG in that model."
5.	Herpesviridae Infections (Herpesvirus Infection) 05/01/1985 - "The metabolism of the drug [2-14C]-1-(2'-deoxy-2'-fluoro-beta-D -arabinofuranosyl)-5-iodocytosine (FIAC), a potent inhibitor of herpesvirus replication, was studied in immunosuppressed patients with herpesvirus infections. " 10/01/1983 - "Phase I evaluation of 2'-fluoro-5-iodo-1-beta-D-arabinofuranosylcytosine in immunosuppressed patients with herpesvirus infection." 10/01/1983 - "We have administered FIAC to 32 host compromised patients, 30 with advanced cancer, who were experiencing acute herpesvirus infections (varicella zoster, 29; HSV-1, 2; HSV-2, 1); the drug was given by 20 min i.v. infusion twice a day for 7 days. "

Related Drugs and Biologics

1.	Vidarabine (Vira-A)
2.	clevudine
3.	Acyclovir (Aciclovir)
4.	fialuridine
5.	Nucleosides
6.	fiacitabine (FIAC)
7.	Interferon-alpha (Interferon Alfa)
8.	Thymine
9.	Thymidine
10.	Idoxuridine (Stoxil)

Related Therapies and Procedures

1.	Therapeutics