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8-chlorocarbochromen (AD 6)

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RN given refers to parent cpd

Also Known As:

AD 6; cloricromen; AD6; 8-chloro-3-beta-diethylaminoethyl-4-methyl-7-ethyoxycarbonymethoxycoumarin; 8-chlorocarbochromen hydrochloride; 8-monochloro-3-beta-diethylaminoethyl-4-methyl-7-ethoxycarboxylmethoxycoumarin; AD(6); cloricromene; Acetic acid, ((8-chloro-3-(2-(diethylamino)ethyl)-4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy)-, ethyl ester

Networked: 73 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- Pyrans: 5
  - Benzopyrans: 11
    - Coumarins: 240
      - Chromonar: 63
        8-chlorocarbochromen: 73
- 2-Ring Heterocyclic Compounds
  - Benzopyrans: 11
    - Coumarins: 240
      - Chromonar: 63
        8-chlorocarbochromen: 73

Experts

1.	Aurisicchio, Luigi: 4 articles (08/2010 - 10/2009)
2.	Ciliberto, Gennaro: 4 articles (08/2010 - 10/2009)
3.	La Monica, Nicola: 4 articles (08/2010 - 10/2009)
4.	Peruzzi, Daniela: 4 articles (08/2010 - 10/2009)
5.	Cuzzocrea, Salvatore: 4 articles (08/2009 - 03/2003)
6.	Mazzon, Emanuela: 4 articles (08/2009 - 03/2003)
7.	Mesiti, Giuseppe: 3 articles (08/2010 - 10/2009)
8.	Bucolo, Claudio: 3 articles (08/2009 - 03/2003)
9.	Conforti, Antonella: 2 articles (08/2010 - 04/2010)
10.	Scarselli, Elisa: 2 articles (08/2010 - 10/2009)

Related Diseases

1.	Inflammation 04/01/2006 - "Intraperitonal injection of cloricromene (10 mg/kg daily for 8 days) significantly decreased all of the parameters of inflammation as described above. " 12/01/2000 - "7. This study provides the first evidence that cloricromene, a coumarine derivative, attenuates the degree of chronic inflammation and tissue damage associated with collagen-induced arthritis in the rat." 06/01/2007 - "These data, along with the previously published potency data for cloricromene, suggest that cloricromene could be potentially useful in ischemic-retinal diseases where amelioration of blood flow and inflammation is desirable." 08/01/2009 - "This study provides the first evidence that the new coumarin derivative cloricromene attenuates the degree of inflammation preserving the BRB in diabetic rats." 03/01/2003 - "This study provides the first evidence that cloricromene, a coumarin derivative, attenuates the degree of inflammation and tissue damage associated with EIU in rats."
2.	Shock 12/01/1999 - "These data confirm that cloricromene exerts a notable inhibitory effect on PMN and may explain the activity of the compound, observed in vivo in several experimental models of ischaemia-reperfusion and shock." 01/14/1992 - "Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats." 07/01/1989 - "In addition, cloricromene (5, 10, and 25 microM) added in vitro to peritoneal macrophages, collected from shocked rats, significantly enhanced their phagocytic activity depressed by shock." 07/01/1989 - "Cloricromene improves survival rate and peritoneal macrophage function in splanchnic artery occlusion shock in rats." 02/01/1991 - "The data suggest that cloricromene exerts beneficial effects in experimental hypovolemic shock, probably reversing myocardial failure."
3.	Leukopenia 04/01/1995 - "Administration of cloricromene (2 mg/kg i.v.), an inhibitor of TNF-alpha, significantly increased survival time (225 +/- 10 min), decreased serum levels of TNF-alpha and sE-selectin, reduced leukopenia and MPO activity in the ileum (0.035 +/- 0.003 U x 10(-3)/g tissue) and lung (0.3 +/- 0.005 U x 10(-3)/g tissue), improved the cardiovascular changes, and reduced the histological changes in the ileum and lung. " 01/14/1992 - "Cloricromene administration (0.5, 1 and 2 mg/kg i.v. 15 min after endotoxin) protected against LPS-induced lethality (100% survival rate 24 h after endotoxin challenge), reverted LPS-induced hypotension and leukopenia, and decreased TNF-alpha in both serum and macrophage supernatants. "
4.	Osteophyte 12/01/2000 - "6. Radiographic signs of protection against bone resorption and osteophyte formation were present in the joints of cloricromene-treated rat. "
5.	Prostatic Neoplasms (Prostate Cancer) 11/01/2012 - "miR122 regulation of Ad6 significantly improves its safety profile after systemic administration, which allows increasing therapeutic doses leading to improved anticancer efficacy of systemic treatment of castration-resistant prostate cancer."

Related Drugs and Biologics

1.	coumarin
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Ethanol (Ethyl Alcohol)
4.	DNA (Deoxyribonucleic Acid)
5.	Antigens
6.	Antibodies
7.	A-Form DNA (A-DNA)
8.	Tacrine (Cognex)
9.	Superoxides (Superoxide)
10.	Chromonar (Carbocromen)

Related Therapies and Procedures

1.	Castration
2.	Stapes Surgery (Stapedectomy)
3.	Drug Therapy (Chemotherapy)
4.	Aftercare (After-Treatment)