CCI 17810

inhibits thrombus formation in CFY rats

Also Known As:

6-(p-(4-phenylacetylpiperazin-1-yl)phenyl)-4,5-dihydro-3(2H)pyridazone; CCI-17810; Piperazine, 1-(phenylacetyl)-4-(4-(1,4,5,5-tetrahydro-6-oxo-3pyridazinyl)phenyl); Piperazine, 1-(phenylacetyl)-4-(4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - CCI 17810: 3

Related Diseases

1.	Thrombocytopenia (Thrombopenia) 04/01/1981 - "3. In mice, single oral doses of CCI 17810 in the range 12.5 to 100 mg/kg inhibited collagen-induced thrombocytopenia. " 01/15/1987 - "The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg). " 04/01/1981 - "Arachidonic acid-induced mortality was markedly reduced by 10 mg/kg and possibly slightly reduced by 1 mg/kg. Aspirin was considerably less active than CCI 17810 in inhibiting collagen-induced thrombocytopenia but was almost as active as CCI 17810 in reducing arachidonic acid-induced mortality. "
2.	Thrombosis (Thrombus) 08/29/1980 - "Both the incidence of occlusion of the cannulated artery and the mean thrombus weight were reduced by CCI 17810 in doses of 25, 50 or 100 mg/kg administered orally twice daily; the effects were dose-related. " 08/29/1980 - "6-[p-(4-Phenylacetylpiperazin-1-yl)-phenyl]-4,5-dihydro-3(2H)-pyridazinone (CCI 17810) inhibited thrombus formation in CFY rats. "

Related Drugs and Biologics

1.	Arachidonic Acid (Vitamin F)
2.	Batroxobin
3.	Heparin (Liquaemin)
4.	Collagen
5.	Aspirin (Acetylsalicylic Acid)
6.	clocoumarol