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CCI 17810
inhibits thrombus formation in CFY rats
Also Known As:
6-(p-(4-phenylacetylpiperazin-1-yl)phenyl)-4,5-dihydro-3(2H)pyridazone; CCI-17810; Piperazine, 1-(phenylacetyl)-4-(4-(1,4,5,5-tetrahydro-6-oxo-3pyridazinyl)phenyl); Piperazine, 1-(phenylacetyl)-4-(4-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)phenyl)-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
CCI 17810: 3
Related Diseases
1.
Thrombocytopenia (Thrombopenia)
04/01/1981 - "
3. In mice, single oral doses of CCI 17810 in the range 12.5 to 100 mg/kg inhibited collagen-induced thrombocytopenia.
"
01/15/1987 - "
The long-lasting thrombocytopenia was inhibited by heparin (4 mg/Kg), defibrase (20 U/Kg), clocoumarol (4 mg/Kg) and CCI 17810 (120 mg/Kg).
"
04/01/1981 - "
Arachidonic acid-induced mortality was markedly reduced by 10 mg/kg and possibly slightly reduced by 1 mg/kg. Aspirin was considerably less active than CCI 17810 in inhibiting collagen-induced thrombocytopenia but was almost as active as CCI 17810 in reducing arachidonic acid-induced mortality.
"
2.
Thrombosis (Thrombus)
08/29/1980 - "
Both the incidence of occlusion of the cannulated artery and the mean thrombus weight were reduced by CCI 17810 in doses of 25, 50 or 100 mg/kg administered orally twice daily; the effects were dose-related.
"
08/29/1980 - "
6-[p-(4-Phenylacetylpiperazin-1-yl)-phenyl]-4,5-dihydro-3(2H)-pyridazinone (CCI 17810) inhibited thrombus formation in CFY rats.
"
Related Drugs and Biologics
1.
Arachidonic Acid (Vitamin F)
2.
Batroxobin
3.
Heparin (Liquaemin)
4.
Collagen
5.
Aspirin (Acetylsalicylic Acid)
6.
clocoumarol