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sauvagine

isolated from skin of South American hylid frog, Phyllomedusa sauvagei; has hypotensive & antidiuretic effect; potent stimulating action on secretion of ACTH & corticosterone; inhibitory effect on secretion of PRL, GH, & TSH; consists of straight chain of 40 amino acid residues

Also Known As:

(D-Phe(11),His(12),Nle(17))Svg(11-40); 0-Tyr-sauvagine; 11-D-Phe-12-His-17-Nle-Svg(11-40); C-terminal sauvagine(17-40); K 41498; K-41498; K41498; aSvg-30, Nle(17)-; sauvagine (11-40), D-Phe(11)-His(12)-Nle(17)-; sauvagine (11-40), D-phenylalanyl(11)-histidyl(12)-norleucyl(17)-; sauvagine(17-40); sauvagine, Tyr(0)-; sauvagine, tyrosyl(0)-; Sauvagin

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tscheiner, Michelle: 2 articles (05/2005 - 01/2005)
2.	Mazur, Adam W: 2 articles (05/2005 - 01/2005)
3.	Donnelly, Elizabeth: 2 articles (05/2005 - 01/2005)
4.	Wang, Feng: 2 articles (05/2005 - 01/2005)
5.	Isfort, Robert J: 2 articles (05/2005 - 01/2005)
6.	Hauger, Richard L: 1 article (09/2013)
7.	Hudson, Christine C: 1 article (09/2013)
8.	Hernandez-Aranda, Judith: 1 article (09/2013)
9.	Dautzenberg, Frank M: 1 article (09/2013)
10.	Olivares-Reyes, J Alberto: 1 article (09/2013)

Related Diseases

1.	Edema 06/25/1997 - "This study investigated whether sauvagine and urotensin I change [Ca2+]i in human epidermoid A-431 cells and whether these changes are correlated with their anti-edema properties in vivo. "
2.	Atrophy 05/01/2005 - "Corticotropin releasing factor 2 receptor selective analogs of the amphibian peptide sauvagine, a member of the corticotropin releasing factor (CRF) peptide family, have therapeutic potential for the treatment of skeletal muscle atrophy. " 01/13/2005 - "Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy." 01/01/2004 - "In addition, we also observed that removal of the adrenals increased the effectiveness of the non-selective CRFR agonists sauvagine, presumably via the removal of the pro-atrophy influence of adrenal produced corticosteroids. "
3.	Hypothermia 06/13/1994 - "In rats kept at an ambient temperature of 22 degrees C, centrally and peripherally administered sauvagine induces a dose-dependent hypothermia. " 03/01/1990 - "Experiments with centrally or peripherally injected sauvagine produced dose-dependent hypothermia in rats kept at ambient temperatures of +4 degrees C and +22 degrees C, but no effect was seen on rats maintained at +34 degrees C. "
4.	Hypotension (Low Blood Pressure) 07/01/1980 - "4. Hypotension is probably the main cause of the intense antidiuresis seen in hydrated rats following sauvagine administration. " 04/01/1981 - "Sauvagine, a linear peptide of 40 amino acids, produced hypotension when administered intravenously to anesthetized dogs. "
5.	Hemorrhagic Shock 01/01/1985 - "We used the Wiggers model of experimental hemorrhagic shock in 20 pentobarbital-anesthetized dogs, giving half the dogs a selective mesenteric dilator peptide, sauvagine, to produce selective dilatation of the superior (cephalic) and inferior (caudal) mesenteric circulations. "

Related Drugs and Biologics

1.	urotensin I
2.	Corticotropin-Releasing Hormone
3.	Urocortins
4.	Vasotocin (Argiprestocin)
5.	Pentobarbital (Nembutal)
6.	Amino Acids
7.	Adrenal Cortex Hormones (Corticosteroids)
8.	astressin