bleomycetin

RN given refers to parent cpd

Also Known As:

N1-(3-((4-aminobutyl)amino)propyl)bleomycinamide; NSC-350895; bleomycetin hydrochloride; bleomycin A5; pingyangmycin; zhengguangmycin A5; bleomycinamide, N(1)-(3-((4-aminobutyl)amino)propyl)-

Networked: 189 relevant articles (30 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycopeptides: 1928
    - Bleomycin: 9833
      - bleomycetin: 189
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Glycopeptides: 1928
    - Bleomycin: 9833
      - bleomycetin: 189

Experts

1.	Chen, Yong: 5 articles (09/2013 - 10/2003)
2.	Zhang, Ling: 4 articles (11/2018 - 01/2013)
3.	Wang, C: 4 articles (04/2017 - 10/2000)
4.	Wang, Hui: 3 articles (07/2022 - 06/2015)
5.	Lin, Xiaoxi: 3 articles (01/2022 - 06/2008)
6.	Jiang, Bo: 3 articles (01/2019 - 08/2013)
7.	Pan, Ximin: 3 articles (01/2019 - 08/2013)
8.	Sun, Haixing: 3 articles (01/2019 - 08/2013)
9.	Zhou, Zhiyu: 3 articles (01/2019 - 08/2013)
10.	Zou, Xuenong: 3 articles (01/2019 - 08/2013)

Related Diseases

1.	Hemangioma (Angioma) 01/01/2013 - "[Therapeutic mechanism of bleomycin A5 on infancy hemangioma: an experimental study]." 01/31/2019 - "A small incision in the ventral penile area was separated from the location of the hemangioma, which was injected with pingyangmycin again. " 01/31/2019 - "It was treated by injection of pingyangmycin into the hemangioma's lumen and base. " 07/01/2014 - "The data demonstrated that the pro‑apoptotic activity of pingyangmycin against infantile hemangiomas involves p53 pathway activation. " 07/01/2014 - "Pingyangmycin stimulates apoptosis in human hemangioma-derived endothelial cells through activation of the p53 pathway."
2.	Neoplasms (Cancer) 01/01/2021 - "To investigate the antitumor efficacy of pingyangmycin (PYM) in combination with anti-PD-1 antibody and determine the capability of PYM to induce immunogenic cell death (ICD) in cancer cells. " 01/01/2004 - "This was to study the signal transduction pathways that might exert the apoptotic effects of bleomycin A5 on tumor cells, as well as to examine the possibility of lower dosing of such drug in combinative treatment with other compounds in vitro. " 01/01/2021 - "Pingyangmycin (PYM) induces DNA damage and has been used for the treatment of oral and maxillofacial tumors. " 08/01/2014 - "The low concentrations of pingyangmycin was injected in 18 cases, and Phase II surgical resection was performed in 6 cases after 6 months, because of the large tumors and a wide range of invasion. " 01/01/2004 - "Previous work has shown that bleomycin A5 exerts its apoptotic effects on tumor cells. "
3.	Carcinoma (Carcinomatosis) 01/01/2022 - "The aim of the study is to investigate the role of pingyangmycin (PYM) in oral carcinoma (OC) cell autophagy via the PI3K/AKT/mTOR axis. " 01/01/2022 - "Pingyangmycin Activates Oral Carcinoma Cell Autophagy via the Phosphorylation of the PI3K/AKT/mTOR Axis to Achieve the Purpose of Treating Oral Carcinoma." 07/01/1993 - "[Cytotoxicity of lymphokine-activated killer cells in conjunction with pingyangmycin to human tongue carcinoma (Tca8113) in vitro and vivo]." 06/01/1992 - "[The antitumor effect of DNL/rIL-2 and Pingyangmycin on human tongue carcinoma(Tca 8113) transplanted to Nude Mice]" 12/01/1980 - "The antitumor effect of bleomycetin on Ehrlich's carcinoma was somewhat less pronounced. "
4.	Squamous Cell Carcinoma of Head and Neck 06/01/2004 - "Pingyangmycin (PYM), a high sensitive anticancer drug for oral squamous cell carcinoma, were selected as model drug. " 10/01/2020 - "The optimal working concentration of pingyangmycin (PYM) was detected by CCK-8 assay, and temperatures of 39, 42, and 45 ℃ were applied to the oral squamous cell carcinoma CAL27, SCC-15, and Tca8113 cell lines. " 06/01/2010 - "The cytotoxic effects of a new formulation of Pingyangmycin-activated carbon nanoparticles (PYM-CH-NP) on two human oral squamous cell carcinoma Tca8113 and BcaCD885 cell lines were studied in vitro. " 05/01/1982 - "Bleomycetin was effective in 75-80, 81.8, 58.3, 70 and 50 per cent of the cases with disseminated derminogenic tumor of the testicle, squamous cell carcinoma of the head and neck, cancer of the penis, carcinoma of the skin and lymphogranulomatosis, respectively. " 06/01/2000 - "23 cases with clinical advanced biopsy-proven oral squamous cell carcinoma received intraarterial chemotherapy with cisplatin (DDP), Pingyangmycin (PYM) and 5-fluorouracilum (5-Fu), at the same time intravenous infusion with natrii thiosulfas (STS) for rescue. "
5.	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 02/28/2017 - "Safety and efficacy of bleomycin/pingyangmycin-containing chemotherapy regimens for malignant germ cell tumor patients in the female genital system." 02/28/2017 - "To comprehensively evaluate the safety and effectiveness of bleomycin/pingyangmycin-containing chemotherapy for female patients with malignant germ cell tumors in their genital system; to assess the diagnostic value of pulmonary function tests for bleomycin-induced pulmonary toxicity. " 01/01/1988 - "When administered by intravenous or intramuscular injection in single or total doses amounting to only 50-70% of those of bleomycin (bleocin), bleomycetin proved effective in the treatment of extended squamous cell carcinoma of the head and neck, skin, cervix uteri, embryonal cancer of the testicle and, particularly, recurrent Hodgkin's disease and non-Hodgkin's lymphoma. " 11/01/1988 - "Efficacy and toxicity of VAB-6 combinations with bleomycin, bleomycetin or peplomycin were studied in treatment of 77 patients with metastases of germ-cell tumors: testicle tumors in 71 patients and extragonadal tumors in 6 patients. " 01/01/2005 - "This drug has been used as cytostatic treatment of many malignant tumors, such as germ cell tumors, lymphomas, head and neck, and Kaposi's sarcomas [Chen XL, Li WB, Zhou AM et al. Role of endogenous peroxynitrite in pulmonary injury and fibrosis induced by bleomycin A5 in rats. "

Related Drugs and Biologics

1.	bleomycetin
2.	Bleomycin (Blenoxane)
3.	Vincristine (Oncovin)
4.	Propranolol (Inderal)
5.	Ethiodized Oil (Ethiodol)
6.	Emulsions
7.	Fluorouracil (Carac)
8.	Carboplatin (JM8)
9.	Polymers
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Therapeutics
2.	Intralesional Injections
3.	Drug Therapy (Chemotherapy)
4.	Gas Lasers
5.	Solid-State Lasers