lofexidine

reduces narcotic withdrawal symptoms; RN given refers to parent cpd without isomeric designation; structure in Negwer, 5th ed, #6247

Also Known As:

2-(alpha-(2,6-dichlorophenoxy)ethyl) delta-2-imidazoline; BritLofex; Lofexidine mono-hydrochloride; Lucemyra; lofexidine hydrochloride; lofexidine monohydrochloride; lofexidine, (+-)-isomer; 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro-

Networked: 79 relevant articles (13 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Imidazolines: 282
        Clonidine: 4528
        lofexidine: 79

Experts

1.	Farrell, M: 4 articles (10/2004 - 01/2001)
2.	Clinch, Thomas: 3 articles (01/2020 - 01/2016)
3.	Gorodetzky, Charles W: 3 articles (05/2019 - 01/2016)
4.	Ling, Walter: 3 articles (01/2011 - 01/2008)
5.	Miotto, Karen: 3 articles (01/2011 - 01/2008)
6.	Li, Jing: 3 articles (01/2009 - 01/2008)
7.	Ali, R: 3 articles (10/2004 - 01/2001)
8.	Gowing, L: 3 articles (10/2004 - 01/2001)
9.	White, J: 3 articles (10/2004 - 01/2001)
10.	Alam, Danesh: 2 articles (01/2020 - 05/2019)

Related Diseases

1.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 01/01/2020 - "Lofexidine, if FDA approved for management of withdrawal symptoms and has been proved to be both effective and safe. " 09/01/2008 - "On the study day 5 MHOWS, subjects treated with lofexidine had significantly lower scores (equating to fewer/less severe withdrawal symptoms) than placebo subjects (least squares means 19.5+/-2.1 versus 30.9+/-2.7; p=0.0019). " 09/01/2020 - "Patients treated with lofexidine experienced mild withdrawal symptoms throughout treatment. " 01/01/2020 - "It covers the background and necessity of withdrawal programs and the management of withdrawal symptoms and then covers the existing evidence of the use of Lofexidine for this purpose. " 12/01/2019 - "If withdrawal symptoms occur, they can be managed, for example, with lofexidine. "
2.	Hypotension (Low Blood Pressure) 07/01/2001 - "Because lofexidine does not produce hypotension, safe outpatient treatment, without hospital support, could be possible." 01/01/2001 - "The lower incidence of hypotension makes lofexidine more suited to use in outpatient settings than lofexidine. " 01/01/1999 - "Such problems of hypotension as were encountered with lofexidine were adequately managed with dose reduction. " 01/01/2020 - "In 1 study that compared lofexidine with placebo, lofexidine caused significant hypotension, bradycardia, and pupillary constriction. " 01/01/2020 - "Hypotension and bradycardia were more common with lofexidine. "
3.	Tic Disorders (Tic Disorder) 03/01/2003 - "Subjects from a specialty tic disorders clinic were randomly assigned to receive 8 weeks of treatment with lofexidine or placebo under double-blind conditions. " 03/01/2003 - "Lofexidine appears to be a safe and effective treatment for children with tic disorders and ADHD." 06/01/2004 - "A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder." 03/01/2003 - "This study evaluated the efficacy and safety of Lofexidine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD). " 03/01/2003 - "A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder."
4.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 03/01/2003 - "After 8 weeks of treatment, lofexidine was associated with a mean improvement of 41% in the total score on the teacher-rated ADHD Rating Scale compared to 7% improvement for placebo. " 03/01/2003 - "Lofexidine appears to be a safe and effective treatment for children with tic disorders and ADHD." 06/01/2004 - "A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder." 03/01/2003 - "This study evaluated the efficacy and safety of Lofexidine in treating children with tic disorders and attention deficit hyperactivity disorder (ADHD). " 03/01/2003 - "A placebo-controlled study of lofexidine in the treatment of children with tic disorders and attention deficit hyperactivity disorder."
5.	Marijuana Abuse (Cannabis Abuse) 02/01/2016 - "The purpose of this study was to evaluate the safety and efficacy of dronabinol, a synthetic form of delta-9-tetrahydrocannabinol, a naturally occurring pharmacologically active component of marijuana, and lofexidine, an alpha-2 agonist, in treating cannabis dependence. " 03/01/2008 - "These data suggest the combination of lofexidine and THC warrant further testing as a potential treatment for marijuana dependence."

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Clonidine (ST 155)
3.	Dronabinol (THC)
4.	Methadone (Dolophine)
5.	Naloxone (Narcan)
6.	Adrenergic Agonists (Adrenergic Receptor Agonist)
7.	Naloxone Drug Combination Buprenorphine
8.	Naltrexone (ReVia)
9.	Opiate Alkaloids
10.	Cannabinoid Receptor Agonists

Related Therapies and Procedures

1.	Secondary Prevention
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Critical Care (Surgical Intensive Care)