steroid 16-beta-hydroxylase

cytochrome P-450 enzyme that catalyzes 16-beta-hydroxylation of testosterone, androstenedione, or estrone; include several members of the P-450 2B subfamily

Also Known As:

4-androstene-3,17-dione-16 beta-hydroxylase; CYP 2B2; CYP2B2; P450 PB4; P450E; TTT 16 beta-hydroxylase; cytochrome P-450 CYP2B2 (rat); cytochrome P450 2B2; steroid 16-hydroxylase; steroid hormone 16-beta-hydroxylase; testosterone 16 beta-hydroxylase

Networked: 9 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	A, Li-Sha: 1 article (04/2021)
2.	Ba, Gen-Na: 1 article (04/2021)
3.	Bai, Ta-Na: 1 article (04/2021)
4.	Cho, Sung-Bo: 1 article (04/2021)
5.	Dai, Li-Li: 1 article (04/2021)
6.	Fu, Ming-Hai: 1 article (04/2021)
7.	Gong, Ju-Hua: 1 article (04/2021)
8.	Jin, Wen-Jie: 1 article (04/2021)
9.	Tong, Shan: 1 article (04/2021)
10.	Wang, Huan: 1 article (04/2021)

Related Diseases

1.	Peptic Ulcer (Peptic Ulcers) 04/28/2021 - "Downregulation of CYP2b2 and UGT2b1 genes in retinol metabolism and upregulation of A2m and MASP1 genes in the complement and coagulation cascades pathways are possibly involved in SL-4-mediated protection against gastroduodenal ulcer."
2.	Hepatocellular Carcinoma (Hepatoma) 03/01/2009 - "Using human HepG2 and rat H4IIEC3 hepatoma cell lines, we found that dexamethasone induction of CYP2B2 and Cyp2b10 luciferase reporters required the glucocorticoid receptor. " 01/01/2010 - "Quantitative real time-polymerase chain reaction (QRT-PCR) and immunoblots were used to assess messenger RNA (mRNA) and protein expression for CYP2B2, CYP3A1, CYP3A2, CYP3A9, ABCB1a, ABCB1b, ABCC1, ABCC2, pregnane X receptor (PXR), farnesoid X receptor (FXR) and constituitive androstane receptor (CAR) in rat hepatoma cell line H411E, intestinal cells, Iec-6, and rat primary hepatocytes, in response to exposure for 18 h with prototypical inducers. " 03/01/2018 - "In this study, the effects of chiral pesticide metalaxyl on CYP1A1, CYP1A2, CYP2B1, CYP2B2, CYP2E1 and CYP3A were investigated in human hepatoma HepG2, rat hepatic H4IIE, chicken hepatic LMH and grass carp hepatic L8824 cells. "
3.	Carcinogenesis 07/01/2008 - "The results suggest that interactions of DIM, and/or its mono-hydroxy metabolites, with CYP2B1 and CYP2B2 found to occur in hepatic microsomes upon addition of DIM or co-treatment of rats with DIM affect the rates of relevant oxidations of E2, and potentially protect against estrogen-dependent tumorigenesis." 03/17/1992 - "Their regioselectivity for DMBA metabolism paralleled that of the respective purified rat liver enzymes and reproduced previously reported regioselective differences between CYP2B1 and CYP2B2 [Wilson et al. (1984) Carcinogenesis 5, 1475-1483]. "
4.	Sepsis (Septicemia) 09/01/2008 - "Additionally, four genes were associated with an age-dependent response to sepsis: CYP2B2 (cytochrome P450, family 2, subfamily B, polypeptide 6), VGLL2 (vestigial like 2), and PAH (phenylalanine hydroxylase). "
5.	Starvation 07/01/1996 - "induction of CYP2B1, CYP2B2, and CYP3A1 by HCB was decreased 3-fold when starvation during the final 24 hr was replaced by continuous feeding. "

Related Drugs and Biologics

1.	Vitamin A (Retinol)
2.	Complement System Proteins (Complement)
3.	Cytochrome P-450 CYP2B1 (PROD)
4.	Cytochrome P-450 CYP3A
5.	Cytochrome P-450 CYP2E1 (CYP2E1)
6.	Cytochrome P-450 CYP1A2 (CYP1A2)
7.	Cytochrome P-450 CYP1A1 (CYP1A1)
8.	Pesticides
9.	metalaxyl
10.	Messenger RNA (mRNA)