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sitosterol (beta-sitosterol)

RN given refers to cpd without isomeric designation; structure in first source

Also Known As:

beta-sitosterol; clionasterol; 24-ethylcholest-5-en-3 beta-ol; 24-ethylcholesterol; 3beta-sitosterol; 3beta-stigmast-5-en-3-ol; Harzol; sitosterol, (3beta)-isomer; sitosterol, (3beta,24S)-isomer; sitosterol, (3beta,24xi)-isomer; sitosterol, 26-(14)C-labeled; Stigmast-5-en-3-ol

Networked: 267 relevant articles (17 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 56
- Steroids: 18537
  - Cholestanes
    - Sterols: 480
      - Phytosterols: 402
        Sitosterols: 3
        sitosterol: 267
    - Cholestenes
      - Sitosterols: 3
        sitosterol: 267

Experts

1.	Fink, Carol S: 6 articles (01/2009 - 03/2003)
2.	Awad, Atif B: 6 articles (01/2009 - 03/2003)
3.	Fink, C S: 6 articles (11/2007 - 01/2000)
4.	Awad, A B: 6 articles (11/2007 - 01/2000)
5.	Lütjohann, Dieter: 5 articles (05/2015 - 04/2006)
6.	Ignacimuthu, Savarimuthu: 4 articles (04/2012 - 01/2010)
7.	Choi, Yung Hyun: 4 articles (06/2008 - 12/2003)
8.	Mannarino, Elmo: 3 articles (03/2013 - 02/2012)
9.	Pirro, Matteo: 3 articles (03/2013 - 02/2012)
10.	Siepi, Donatella: 3 articles (03/2013 - 02/2012)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2015 - "Although β-sitosterol is effective against enlarged prostate in human clinical trials and has anti-cancer and anti-inflammatory activities, the mechanisms of action are poorly understood. " 11/01/2013 - "The obtained results evidenced that the studied herein modifications in the composition of Chol/SM/GM3 monolayer, reflecting compositional alterations induced by phytosterol in cancer membranes, strongly affect the organization of model system, therefore they should be considered in the studies on anticancer mechanism of β-sitosterol. " 06/14/2012 - "Experimental results of this study suggest that γ-Sitosterol exerts potential anticancer activity through the growth inhibition, cell cycle arrest and the apoptosis on cancer cells." 06/14/2012 - "This study demonstrates in vitro results, which support the ethnomedical use of γ-Sitosterol against cancer. " 01/01/2003 - "This study provides additional evidence that kimchi and its active components, including beta-sitosterol, have potential in both the prevention and treatment of cancer, and presents convincing evidence that the anticancer effects may be a result of an inhibition of Ras oncogene signaling."
2.	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 06/17/1995 - "Significant improvement in symptoms and urinary flow parameters show the effectiveness of beta-sitosterol in the treatment of benign prostatic hyperplasia." 06/01/1999 - "To conduct a systematic review of the evidence for the efficacy of beta-sitosterol in men with symptomatic benign prostatic hyperplasia (BPH). " 12/01/1998 - "[Clinical effects of beta-sitosterol (phytosterol) on benign prostatic hyperplasia: preliminary study]." 09/01/1997 - "To report the results of a double-blind, placebo-controlled trial to evaluate Azuprostat, a beta-sitosterol, in patients with symptoms of outlet obstruction caused by benign prostatic hyperplasia (BPH). " 05/01/2000 - "Treatment of symptomatic benign prostatic hyperplasia with beta-sitosterol: an 18-month follow-up."
3.	Necrosis 04/01/1958 - "[Raynaud's syndrome with necrosis of the pulp of the left middle finger, cured by sitosterol]." 06/30/1992 - "The preoperative proportions of cholestanol were 12 and 3-times higher in the PBC and necrosis groups, respectively, than in a control group of 27 individuals, while those of lathosterol were low in both groups and the campesterol/sitosterol ratio in the PBC group. " 01/01/2013 - "To evaluate the effect of β-sitosterol on ⁴⁵Ca²⁺ uptake in activated murine neutrophils, and upon myeloperoxidase and adenosine deaminase activity, and interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) levels, in carrageenan-induced inflammation in the mouse air pouch model. " 06/30/1992 - "During the postoperative follow-up of 5 weeks the proportions of the non-cholesterol sterols were markedly improved especially in the necrosis group yet those of cholestanol remained high and the campesterol/sitosterol ratios low, particularly in the PBC group. " 06/30/1992 - "Proportions of cholesterol precursors (squalene, delta 8-cholestenol, desmosterol and lathosterol), plant sterols (campesterol and sitosterol) and cholestanol to cholesterol in serum were measured before and serially after liver transplantation in eight patients with primary biliary cirrhosis (PBC) and three with acute liver necrosis. "
4.	Hypercholesterolemia 11/24/1978 - "In a trial with 59 outpatients with hypercholesterolemia the effect of two different doses of 5.28 and 10,56 g Beta-Sitosterol was compared to placebo. " 02/15/2015 - "β-Sitosterol reduced plasma TC by 17.4% and 11.6%, respectively, in FC-induced and CP-induced hypercholesterolemia (not significant). " 02/01/2014 - "High efficiency for combined use of polyprenyl phosphate and β-sitosterol, which leads to substantial enhancement of the ability to overcome hypercholesterolemia versus the individual constituents will be demonstrated. " 10/19/1990 - "[Beta-sitosterol in the treatment of hypercholesterolemia]." 01/01/1962 - "[Longterm treatment of human hypercholesterolemia by beta-sitosterol]."
5.	Inflammation 01/10/2011 - "Moreover, treatment with β-sitosterol protected against airway inflammation in lung tissue histopathology. " 05/01/1999 - "The effects of B-sitosterol (BSS) and B-sitosterol glucoside (BSSG) mixture on selected immune parameters of marathon runners: inhibition of post marathon immune suppression and inflammation." 03/01/2001 - "In the present study, following fractionation of the methanol extract of cactus stems guided by adjuvant-induced chronic inflammation model in mice, an active anti-inflammatory principle has been isolated and identified as beta-sitosterol." 05/01/2014 - "β-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-κB pathway." 07/01/2003 - "Sinalbin and beta-sitosterol have anti-androgen and anti-inflammation activities."

Related Drugs and Biologics

1.	Cholesterol
2.	campesterol
3.	Phytosterols (Plant Sterols)
4.	Cholestanol (Coprostanol)
5.	Vitamin E
6.	Ovalbumin
7.	1-Butanol (n Butanol)
8.	Petrolatum (Vaseline)
9.	Bezafibrate
10.	Sterols

Related Therapies and Procedures

1.	Cryotherapy (Therapy, Cold)
2.	Occlusive Dressings (Occlusive Dressing)
3.	Phytotherapy (Herbal Therapy)
4.	Lasers (Laser)
5.	Liver Transplantation