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diacetylrhein (diacerein)

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chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase;

Also Known As:

diacerein; Art brand of diacetylrhein; Negma brand of diacetylrhein; Niverpharm brand of diacetylrhein; Zondar; diacerhein; diacetyl-rhein; 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-

Networked: 132 relevant articles (25 outcomes, 39 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Dougados, M: 5 articles (02/2008 - 10/2001)
2.	Dhaneshwar, Suneela: 4 articles (01/2015 - 01/2013)
3.	Jain, Achint: 3 articles (09/2015 - 05/2013)
4.	Singh, Sanjay: 3 articles (09/2015 - 05/2013)
5.	Patil, Dipmala: 3 articles (01/2015 - 01/2013)
6.	Stoltz, J F: 3 articles (01/2010 - 01/2008)
7.	Tamura, T: 3 articles (05/2001 - 01/2001)
8.	Singh, Royana: 2 articles (09/2015 - 07/2014)
9.	Hernandez, Arnaldo José: 2 articles (02/2015 - 10/2006)
10.	Singh, Sanjay Kumar: 2 articles (07/2014 - 05/2013)

Related Diseases

1.	Osteoarthritis 01/01/2015 - "In the osteoarthritis diacerein-treated group the results showed an improvement with respect to the OA placebo group in all parameters, although the results were not statistically significant. " 07/12/2002 - "Diacerein has proved to be effective in the treatment of osteoarthritis. " 04/01/2001 - "Diacerein has proved to be effective in the treatment of osteoarthritis (OA). " 01/01/2001 - "Diacerein has proved to be effective in the treatment of osteoarthritis. " 07/01/1993 - "Cultured rabbit joint chondrocytes were exposed to diacerhein (DAR : ART 50, Negma, 10(-6) to 10(-4) M), which has proved effective and safe when given for two months for the treatment of osteoarthritis. "
2.	Pain (Aches) 01/12/2002 - "Diacerein is a drug with prolonged antiosteoarthritis action that has proven efficacy for symptom relief equi-valent to NSAID assessed in terms of pain relief and function: the ECHODIAH study provides arguments favoring its chondromodulating effect." 01/01/2014 - "-quality evidence from six trials (1,283 participants) indicates that diacerein has a small beneficial effect on overall pain (measured on a 100 mm visual analogue scale) at three to 36 months (mean difference (MD) -8.65, 95% confidence interval (CI) -15.62 to -1.68), which is equivalent to a 9% pain reduction in the diacerein group (95% CI -16% to -2%) compared with the placebo group. " 03/01/2010 - "Six trials (seven sub-studies; 1533 patients) contributed to the meta-analysis, revealing a large degree of inconsistency among the trials (I(2)=56%) in regard to pain reduction: the combined ES was -0.24 [95% confidence intervals (CI): -0.39 to -0.08, P=0.003], favouring diacerein. " 04/01/2015 - "Diacerein leads to pain relief, with a superior carryover effect when compared with placebo. " 01/01/2014 - "We confirmed that symptomatic benefit provided by diacerein in terms of pain reduction is minimal. "
3.	Knee Osteoarthritis 06/01/2012 - "To observe the therapeutic efficacy of Qianggu Granule (QGG), Diacerein Capsule (DC), and QGG + DC in treating knee osteoarthritis (KOA, belonging to Gan-Shen insufficiency induced vein stasis syndrome), and to explore the clinical advantages of QGG + DC. " 12/01/2007 - "To determine whether the efficacy of diacerein persists at 2 months after the end of a 3-month treatment period, compared with placebo, in patients with painful knee osteoarthritis (OA). " 06/01/2012 - "[Clinical study of Qianggu granule and diacerein capsule in treating knee osteoarthritis]." 10/01/2009 - "Sixty-four patients of knee osteoarthritis fulfilling American College of Rheumatology Criteria were randomized to receive either diacerein or placebo for 8 weeks, followed by 4 weeks "treatment-free" follow-up in this single-blind, parallel group, post-marketing trial. " 10/01/2009 - "The objective of this study was to evaluate the efficacy and safety of diacerein in early, symptomatic knee osteoarthritis in Indian population. "
4.	Hip Osteoarthritis (Coxarthrosis) 09/25/2006 - "This systematic meta-analysis provides evidence for the symptomatic efficacy of diacerein in the treatment of knee and hip osteoarthritis, with reasonable tolerability." 12/07/2002 - "RADIOGRAPHIC FINDINGS: The ECHODIAH study conducted to evaluate the structure-modifying effect of diacerein in hip osteoarthritis. " 01/12/2002 - "The principal objective of ECHODIAH study conducted in patients with hip osteoarthritis was to evaluate the chondroprotective effect of potential of diacerein compared with placebo. " 11/01/2001 - "Evaluation of the structure-modifying effects of diacerein in hip osteoarthritis: ECHODIAH, a three-year, placebo-controlled trial. " 01/01/2000 - "In this study, Harpagophytum was at least as effective as a reference drug (diacerhein) in the treatment of knee or hip osteoarthritis and reduced the need for analgesic and nonsteroidal anti-inflammatory therapy."
5.	Arthritis (Polyarthritis) 01/01/2008 - "Thus, in conclusion, the results of the present study in a large population of Indian patients indicates that diacerein constitutes a novel approach to the treatment for the short- and long-term symptomatic management in Indian patients with osteo-arthritis of the knee." 01/01/2008 - "The present study was, therefore, undertaken to evaluate the efficacy and tolerability of diacerein in the treatment of osteo-arthritis. " 02/01/2015 - "1) The experimental model produced mild arthritis after three months and severe arthritis after seven months; 2) diacerein reduced the degenerative changes in both knees; 3) HA protected the joint cartilage; 4) Combining the two drugs did not improve the results." 01/01/2008 - "Diacerein has been recently introduced in India for the treatment of osteo-arthritis. " 01/01/2008 - "An open prospective study on postmarketing evaluation of the efficacy and tolerability of diacerein in osteo-arthritis of the knee (DOK)."

Related Drugs and Biologics

1.	Hyaluronic Acid (Hyaluronan)
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.	Gold
4.	Freund's Adjuvant
5.	Carbon Monoxide
6.	oxaceprol (AHP)
7.	Glucosamine (Dona)
8.	rhein
9.	Cytokines
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Viscosupplementation
3.	Mud Therapy (Mud Bath)
4.	Ligation
5.	Intra-Articular Injections