1,4-dioxane (dioxane)

08/01/2023 - "We reviewed and integrated information from recently published studies to update our understanding of the cancer mode of action of 1,4-dioxane. "
02/01/2021 - "Studies demonstrate that with sufficient dose and duration, 1,4-dioxane (1,4-DX) induces liver tumors in laboratory rodent models. "
08/01/2023 - "1,4-Dioxane is an environmental contaminant that has been shown to cause cancer in rodents after chronic high dose exposures. "
08/01/2023 - "An integrated assessment of the 1,4-dioxane cancer mode of action and threshold response in rodents."
12/01/2022 - "This choice hinges on our understanding of the 1,4-dioxane cancer mechanism. "

06/15/2005 - "Upon dehydration at low water activities, dioxane decreases the water content at a given a(w). "
06/15/2005 - "Dioxane sorption isotherm obtained during dehydration resembles a smooth curve. "
05/01/2002 - "HClO4 in dioxane to produce principally 4beta,5alpha-diol 11 (80%) of which acetylation followed by dehydration with SOCl2 yielded 4beta,19-diacetoxy-5-ene compound 14 in good yield. "
05/23/2017 - "Best results for this dehydration were achieved using Burgess' reagent in dioxane under microwave irradiation. "
06/15/2005 - "This behavior suggests that the suppression in the uptake of water during dehydration may be due to a competition for water-binding sites on chymotrypsin by dioxane. "

04/01/1973 - "Dose-response and ultrastructural alterations in dioxane carcinogenesis. "
10/01/2018 - "Furthermore, the DNA repair enzyme MGMT was significantly induced at 5000 ppm 1,4-dioxane, implying that extensive genetic damage exceeded the repair capacity of the cells in the liver and consequently led to liver carcinogenesis. "
08/01/1990 - "Thus the data suggest that 1,4-dioxane is a weak genotoxic carcinogen in addition to being a strong promoter of carcinogenesis (a non-genotoxic carcinogen)."
03/01/1990 - "NTP Toxicology and Carcinogenesis studies were conducted by administering glycidol (94% pure, containing 1.2% 3-methoxy-1,2-propanediol, 0.4% 3-chloro-1,2-propanediol, 2.8% diglycidyl ether, and 1.1% 2,6-dimethanol-1,4-dioxane) in water by gavage to groups of F344/N rats and B6C3F1 mice of each sex for 16 days, 13 weeks, or 2 years. "
05/21/2012 - "Lactone metabolite common to the carcinogens dioxane, diethylene glycol, and N-nitrosomorpholine: aqueous chemistry and failure to mediate liver carcinogenesis in the F344 rat."

01/01/1978 - "The mean body weights of the rats and mice were not consistently affected by the administration of dioxane. "
04/01/2016 - "Daily administration for 1,4-dioxane (100 mg/kg body weight) in drinking water for rats weighing 120 g, except for normal control group. "
11/01/1999 - "1,4-Dioxane is a nongenotoxic hepatocarcinogen but in our previous replicative DNA synthesis (RDS) studies with the [3H]thymidine (TdR)-technique, it failed to increase hepatocyte RDS values when given by gavage to male F344 rats as a single 2000 mg/kg body weight dose. "
01/01/1991 - "Treatment of rats with 1.0% dioxane in the drinking water for 5 days yielded no increase in liver/body weight nor induction of palmitoyl CoA oxidase, indicating that dioxane does not fit into the class of peroxisomal proliferating carcinogens. "

03/07/2011 - "A shock tube and theoretical study on the pyrolysis of 1,4-dioxane."
03/07/2011 - "The dissociation of 1, 2 and 4% 1,4-dioxane dilute in krypton was studied in a shock tube using laser schlieren densitometry, LS, for 1550-2100 K with 56 ± 4 and 123 ± 3 Torr. "
12/28/2011 - "The pyrolysis of ethylene glycol vinyl ether (EGVE), an initial product of 1,4-dioxane dissociation, was examined in a diaphragmless shock tube (DFST) using laser schlieren densitometry (LS) at 57 ± 2 and 122 ± 3 Torr over 1200-1800 K. "