15-keto-13,14-dihydroprostaglandin E2

RN given refers to (5Z,11alpha)-isomer; structure in first source

Also Known As:

13,14-dihydro-15-keto-PGE2; 13,14-dihydro-15-ketoprostaglandin E2; 15-keto-13,14-dihydro-PGE2; 15-keto-13,14-dihydroprostaglandin E2, (11alpha)-isomer; PGEM (13,14-dihydro-15-keto-PGE2); prost-5-en-1-oic acid, 11-hydroxy-9,15-dioxo-, (5Z,11 alpha)-

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yang, Peiying: 2 articles (11/2015 - 09/2008)
2.	Gao, Jie: 1 article (02/2021)
3.	Guo, Ming: 1 article (02/2021)
4.	Kou, Na: 1 article (02/2021)
5.	Li, Changkun: 1 article (02/2021)
6.	Ma, Yan: 1 article (02/2021)
7.	Qu, Hua: 1 article (02/2021)
8.	Shi, Dazhuo: 1 article (02/2021)
9.	Song, Lei: 1 article (02/2021)
10.	Wang, Mingming: 1 article (02/2021)

Related Diseases

1.	Myocardial Infarction 02/01/2021 - "In vivo study of myocardial infarction rats demonstrated that PNS attenuated ASA-induced gastric mucosal injury, which was related to markedly boosted gastric level of 6,15-diketo-13,14-dihydro-prostaglandin (PG)F1α, 13,14-dihydro-15-keto-PGE2 and PGE2 from AA/PG pathway in response to PNS + ASA compared with ASA alone. "
2.	Neoplasms (Cancer) 04/01/1980 - "In hypercalcemic, tumor-bearing rabbits, the plasma concentrations of 13,14-dihydro-15-keto-PGE2 and 13,14-dihydro-15-keto-PGF2 alpha were markedly elevated (in the range of 0.5 to 16 ng/ml). " 11/17/2015 - "Compared with lung tumors from K-Ras mice, the levels of prostaglandin E2 (PGE2) were significantly lower, whereas levels of the PGE2 metabolite 13,14-dihydro-15-keto-PGE2 were significantly higher, in lung tumors from K-ras/COX-2(-/-) mice. " 12/01/1984 - "In all five experiments performed, tumor-bearing mice eating control diets had markedly elevated (average sixfold above control) plasma concentrations of 13,14-dihydro-15-keto-PGE2 (PGE2-M), while in mice bearing HSDM1 tumors and eating the EPA-enriched menhaden oil diet, the elevation was reduced to only twice control values. " 04/01/1978 - "PGE2 secreted by the tumor is rapidly metabolized and can be measured in plasma as the metabolite 13,14-dihydro-15-keto-PGE2 (PGE2-M). " 11/17/2015 - "Taken together, these findings suggest that COX-2 deletion contributes to the repression of K-ras-induced lung tumorigenesis by reducing tumor cell proliferation, decreasing the production of PGE2, and increasing the production of 13,14-dihydro-15-keto-PGE2, possibly via the MAPK pathway. "
3.	Carcinogenesis 11/17/2015 - "Taken together, these findings suggest that COX-2 deletion contributes to the repression of K-ras-induced lung tumorigenesis by reducing tumor cell proliferation, decreasing the production of PGE2, and increasing the production of 13,14-dihydro-15-keto-PGE2, possibly via the MAPK pathway. "
4.	Diabetic Ketoacidosis (Ketoacidosis, Diabetic) 09/01/1986 - "Plasma level of 13,14-dihydro-15-keto-PGE2 in patients with diabetic ketoacidosis and in normal fasting subjects." 09/01/1986 - "Plasma levels of 13,14-dihydro-15-keto-PGE2, a stable derivative of PGE2, are elevated in rats with diabetic ketoacidosis (DKA) and decrease in response to insulin therapy. "
5.	Lung Neoplasms (Lung Cancer) 09/01/2008 - "Similar to NSCLC, amounts of PGE1, PGE2, and PGF(2alpha) were markedly increased whereas levels of 13,14-dihydro-15-keto-PGE2 were decreased in the lungs of 15-PGDH knockout mice compared with wild-type mice or when 15-PGDH was silenced in A549 lung cancer cells. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	6-Ketoprostaglandin F1 alpha (6 Ketoprostaglandin F1 alpha)
3.	Streptozocin (Streptozotocin)
4.	Prostaglandins F
5.	Prostaglandins
6.	Insulin (Novolin)
7.	Alprostadil (Muse)
8.	15-hydroxyprostaglandin dehydrogenase
9.	Menhaden oil

Related Therapies and Procedures

1.	Therapeutics