15- hydroperoxy- 5,8,11,13- eicosatetraenoic acid

RN given refers to cpd without isomeric designation; (S-(E,Z,Z,Z))-isomer caused dose-dependent constriction of cat coronary arteries; structure in first source

Also Known As:

14,15-epoxyarachidonic acid; 15-HPAA; 15-HPEA; 15-HPETE; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (E,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (S)-(E,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (Z,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,14-eicosatetraenoic acid; 15-hydroperoxyarachidonic acid; arachidonic acid 15-hydroperoxide; 5,8,11,13-eicosatetraenoic acid, 15-hydroperoxy-

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kalangi, Suresh Kumar: 1 article (09/2019)
2.	Reddanna, Pallu: 1 article (09/2019)
3.	Schäfer-Korting, Monika: 1 article (09/2019)
4.	Wolff, Christopher: 1 article (09/2019)
5.	Zoschke, Christian: 1 article (09/2019)
6.	Cao, Yu-Zhang: 1 article (05/2005)
7.	Corl, Chris: 1 article (05/2005)
8.	Mullarky, Isis K: 1 article (05/2005)
9.	Sordillo, Lorraine M: 1 article (05/2005)
10.	Sylte, Matt J: 1 article (05/2005)

Related Diseases

1.	Hyperalgesia 09/01/1997 - "4. The results of the present study suggest that the release of 15-HPETE into the airways could contribute to sensitization of afferent nerve endings analogous to the hyperalgesia induced by this mediator in skin."
2.	Thrombosis (Thrombus) 01/01/1980 - "The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis." 12/01/1979 - "The effect of 15-hydroperoxyarachidonic acid on the arterial wall during ADP-induced local platelet thrombosis."
3.	Atherosclerosis 02/01/1990 - "The interaction between platelets and endothelium was augmented in RbAs from animals with atherosclerosis and in RbAs pretreated with aspirin (110 microM) or 15-HPETE (150 microM) or by the enzymatic system generating oxygen free radicals (xanthine:xanthine oxidase - 100 microM: 0.1 U/ml). "
4.	Mitochondrial Diseases (Mitochondrial Disease) 05/01/2005 - "Increased exposure to 15-HPETE induced apoptosis, as determined by internucleosomal DNA fragmentation, chromatin condensation, caspase-3 activation, and caspase-9 activation, which suggests mitochondrial dysfunction. "
5.	Hypocapnia 10/01/1984 - "15-HPETE induced arteriolar dilation during application, sustained dilation 1 h after washout, and reduced responsiveness to the vasoconstrictive effects of hypocapnia. "

Related Drugs and Biologics

1.	Caspase 9
2.	Caspase 3 (Caspase-3)
3.	Xanthine
4.	Xanthine Oxidase
5.	Oxygen (Dioxygen)
6.	Histamine (Histamine Dihydrochloride)
7.	Free Radicals
8.	Chromatin
9.	Aspirin (Acetylsalicylic Acid)
10.	Adenosine Diphosphate (ADP)