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benzyloxycarbonylphenylalanylalanine diazomethyl ketone
selective inhibitor of thiol proteinases
Also Known As:
N-CBZ-phenylalanyl-alanine-diazomethyl ketone; Z-FA-DMK; Z-Phe-Ala-CHN2; ZDAP cpd
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Azo Compounds: 333
Diazonium Compounds: 3
Diazomethane: 26
benzyloxycarbonylphenylalanylalanine diazomethyl ketone: 2
Experts
1.
Caffrey, Conor R
: 1 article (02/2007)
2.
Scory, Stefan
: 1 article (02/2007)
3.
Steverding, Dietmar
: 1 article (02/2007)
4.
Stierhof, York-Dieter
: 1 article (02/2007)
Related Diseases
1.
Infections
04/01/1999 - "
brucei decreased to undetectable levels for 3 days following treatment with 250 mg/kg Z-Phe-Ala-CHN2 on days 3 to 6 after infection.
"
02/28/2007 - "
Following daily intra-peritoneal administration of 250 mg kg(-1) of Z-Phe-Ala-CHN2 on days three and four post infection (p.i.), stumpy-like forms with enlarged lysosomes were evident by day five p.i. In addition, trypanosomes exposed to the inhibitor had a 65% greater protein content than those from control mice.
"
Related Drugs and Biologics
1.
Proteins (Proteins, Gene)