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5-methoxymethyl-2'-deoxyuridine
used in treatment of experimental herpes simplex keratitis
Also Known As:
2'-deoxy-5-methoxymethyluridine; 5-methoxymethyldeoxyuridine; MMUdR; 2'-deoxy-5-(methoxymethyl)uridine
Networked:
3
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrimidines: 510
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
5-methoxymethyl-2'-deoxyuridine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
Nucleosides: 6847
Pyrimidine Nucleosides: 50
Uridine: 1186
Deoxyuridine: 331
5-methoxymethyl-2'-deoxyuridine: 3
Deoxyribonucleosides: 34
Deoxyuridine: 331
5-methoxymethyl-2'-deoxyuridine: 3
Related Diseases
1.
Herpetic Keratitis
01/01/1980 - "
Comparative efficacy of 5-methoxymethyl-2'-deoxyuridine, 9 beta-D-arabinofuranosyladenine and 5-iodo-2'-deoxyuridine in the treatment of experimental herpes simplex keratitis.
"
01/01/1980 - "
The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits.
"
2.
Keratitis
01/01/1980 - "
At 5% concentration, Ara-A provided essentially the same protection against herpes keratitis as 0.1% IUdR, while MMUdR was slightly less effective.
"
01/01/1980 - "
The simultaneous application of 2% MMUdR and 2% Ara-A in combination was more effective than 5% MMUdR alone and was effective as 5% Ara-A or 0.1% IUdR in controlling the viral keratitis.
"
3.
Infections
01/01/1986 - "
Efficacy of 5-methoxymethyl-2'-deoxyuridine in combination with arabinosyladenine for the treatment of primary herpes simplex genital infection of mice and guinea pigs.
"
4.
Herpes Genitalis (Genital Herpes)
01/01/1986 - "
The relative efficacy of 5-methoxymethyl-2'-deoxyuridine (MMdUrd), arabinosyladenine (ara-A) and the combination of MMdUrd and ara-A in the treatment of experimental genital herpes (GH) was investigated using mouse and guinea pig models.
"
01/01/1986 - "
Efficacy of 5-methoxymethyl-2'-deoxyuridine in combination with arabinosyladenine for the treatment of primary herpes simplex genital infection of mice and guinea pigs.
"
5.
Drug-Related Side Effects and Adverse Reactions
12/01/1975 - "
The inhibition of HSV-1 by MMUdR appeared to be the result of interference with virus replication rather than the result of drug toxicity to host cells.
"
Related Drugs and Biologics
1.
Vidarabine (Vira-A)
2.
5-methoxymethyl-2'-deoxyuridine
3.
Idoxuridine (Stoxil)