5-methoxymethyl-2'-deoxyuridine

used in treatment of experimental herpes simplex keratitis

Also Known As:

2'-deoxy-5-methoxymethyluridine; 5-methoxymethyldeoxyuridine; MMUdR; 2'-deoxy-5-(methoxymethyl)uridine

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Uridine: 1186
        Deoxyuridine: 331
        5-methoxymethyl-2'-deoxyuridine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Uridine: 1186
      - Deoxyuridine: 331
        5-methoxymethyl-2'-deoxyuridine: 3
  - Deoxyribonucleosides: 34
    - Deoxyuridine: 331
      - 5-methoxymethyl-2'-deoxyuridine: 3

Related Diseases

1.	Herpetic Keratitis 01/01/1980 - "Comparative efficacy of 5-methoxymethyl-2'-deoxyuridine, 9 beta-D-arabinofuranosyladenine and 5-iodo-2'-deoxyuridine in the treatment of experimental herpes simplex keratitis." 01/01/1980 - "The relative efficacy of 5-methoxymethyldeoxyuridine (MMUdR), adenine arabinoside (Ara-A), 5-iododeoxyuridine (IUdR) and the combination of MMUdR and Ara-A in the treatment of experimental herpes simplex keratitis was investigated in rabbits. "
2.	Keratitis 01/01/1980 - "At 5% concentration, Ara-A provided essentially the same protection against herpes keratitis as 0.1% IUdR, while MMUdR was slightly less effective. " 01/01/1980 - "The simultaneous application of 2% MMUdR and 2% Ara-A in combination was more effective than 5% MMUdR alone and was effective as 5% Ara-A or 0.1% IUdR in controlling the viral keratitis."
3.	Infections 01/01/1986 - "Efficacy of 5-methoxymethyl-2'-deoxyuridine in combination with arabinosyladenine for the treatment of primary herpes simplex genital infection of mice and guinea pigs."
4.	Herpes Genitalis (Genital Herpes) 01/01/1986 - "The relative efficacy of 5-methoxymethyl-2'-deoxyuridine (MMdUrd), arabinosyladenine (ara-A) and the combination of MMdUrd and ara-A in the treatment of experimental genital herpes (GH) was investigated using mouse and guinea pig models. " 01/01/1986 - "Efficacy of 5-methoxymethyl-2'-deoxyuridine in combination with arabinosyladenine for the treatment of primary herpes simplex genital infection of mice and guinea pigs."
5.	Drug-Related Side Effects and Adverse Reactions 12/01/1975 - "The inhibition of HSV-1 by MMUdR appeared to be the result of interference with virus replication rather than the result of drug toxicity to host cells. "

Related Drugs and Biologics

1.	Vidarabine (Vira-A)
2.	5-methoxymethyl-2'-deoxyuridine
3.	Idoxuridine (Stoxil)