Geraniin

in various plants; structure in first source

Also Known As:

beta-D-glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy(1,1'-biphenyl)-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), cyclic 2-2:4-1-ester with 2-(2-carboxy-4,5,6-trioxo-2-cyclohexen-1-yl)-3,4,5-trihydroxybenzoic acid

Networked: 54 relevant articles (7 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Palanisamy, Uma D: 6 articles (03/2022 - 11/2017)
2.	Chen, Peng: 5 articles (01/2022 - 02/2013)
3.	He, Bo: 5 articles (01/2022 - 02/2013)
4.	Shen, Zhiqiang: 4 articles (01/2022 - 02/2015)
5.	Yang, Renhua: 4 articles (01/2022 - 02/2015)
6.	Zhang, Xiaochao: 4 articles (01/2022 - 02/2015)
7.	Moorthy, Mohanambal: 3 articles (03/2022 - 01/2018)
8.	Li, Ji: 2 articles (07/2022 - 06/2016)
9.	Choi, Jang-Gi: 2 articles (08/2021 - 01/2019)
10.	Chung, Hwan-Suck: 2 articles (08/2021 - 01/2019)

Related Diseases

1.	Infections 11/21/2017 - "Geraniin was observed to be most effective when added at the early stage of DENV-2 infection. " 01/01/2019 - "The in vivo efficacy of geraniin in inhibiting DENV-2 infection was then tested using BALB/c mice with geraniin administered at three different times. " 05/15/2020 - "The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant Phyllanthus phillyreifolius Inhibits Zika and Dengue Virus Infection at Non-Toxic Effect Doses in Zebrafish." 04/04/2007 - "The 50% inhibitory concentration (IC(50)) was 18.4+/-2.0 microM for geraniin against HSV-2 infection, and 19.2+/-4.0 microM for 1346TOGDG against HSV-1. " 04/04/2007 - "Results showed that geraniin actively suppressed HSV-2 infection, whereas 1346TOGDG effectively inhibited HSV-1 infection. "
2.	Osteoporosis 01/01/2019 - "Geraniin, a polyphenolic compound isolated from Phyllanthus amarus, is effective in preventing osteoporosis, but the mechanisms of action of geraniin and the impact of osteoporotic condition on drug action are not known. " 03/01/2018 - "Our previous study demonstrated that geraniin could alleviate osteoporosis by accelerating bone formation, but the mechanism remains unclear. " 02/01/2015 - "In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. " 02/01/2015 - "These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis. " 06/01/2021 - "In the current experimental study, we planned to scrutinize the therapeutic potential of geraniin against ovariectomy (OVX)-induced osteoporosis in rats and find the possible mechanism. "
3.	Neuroinflammatory Diseases 09/01/2020 - "This was the first study to support further understanding of geraniin as a promising agent against neurotoxicity in the reduction of oxidative stress and neuroinflammation." 09/11/2019 - "This study sought to evaluate the protective effects and underlying mechanisms of geraniin on lipopolysaccharide (LPS)-induced neuroinflammation and neurobiological alternations as well as cognitive impairment. " 09/11/2019 - "These results indicate that geraniin mitigates LPS-elicited neural/synaptic neurodegeneration, amyloidogenesis, neuroinflammation, and cognitive impairment and suggest geraniin as a therapeutic option for neuroinflammation-associated neurological disorders, such as Alzheimer's disease."
4.	Cognitive Dysfunction 09/11/2019 - "This study sought to evaluate the protective effects and underlying mechanisms of geraniin on lipopolysaccharide (LPS)-induced neuroinflammation and neurobiological alternations as well as cognitive impairment. " 09/11/2019 - "These results indicate that geraniin mitigates LPS-elicited neural/synaptic neurodegeneration, amyloidogenesis, neuroinflammation, and cognitive impairment and suggest geraniin as a therapeutic option for neuroinflammation-associated neurological disorders, such as Alzheimer's disease." 09/11/2019 - "Geraniin Attenuates Lipopolysaccharide-Induced Cognitive Impairment in Mice by Inhibiting Toll-Like Receptor 4 Activation."
5.	Osteolysis 01/01/2015 - "Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model." 01/01/2015 - "In this study, we demonstrated for the first time that geraniin, an active natural compound derived from Geranium thunbergii, ameliorated particle-induced osteolysis in a Ti particle-induced mouse calvaria model in vivo. " 01/01/2015 - "Collectively, our data suggested that geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo. " 01/01/2015 - "Geraniin is therefore a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. "

Related Drugs and Biologics

1.	Lipopolysaccharides
2.	Adiponectin
3.	RNA (Ribonucleic Acid)
4.	LDL Lipoproteins (beta Lipoproteins)
5.	Cholesterol
6.	lipopolysaccharide-binding protein
7.	ellagitannin
8.	Antiviral Agents (Antivirals)
9.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
10.	Oseltamivir (Tamiflu)

Related Therapies and Procedures

1.	Ovariectomy (Oophorectomy)
2.	Prostheses and Implants (Prosthesis)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Oral Administration