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lysyllysine (Lys-Lys)

RN given refers to (L-Lys)-isomer
Also Known As:
Lys-Lys; L-Lys-L-Lys; L-lysyl-L-lysine; dilysine; lysyllysine dihydrochloride; lysyllysine hydrochloride; lysyllysine mono-trifluoroacetate; L-lysine, N(2)-L-lysyl-
Networked: 103 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Matsuo, Keitaro: 5 articles (01/2019 - 03/2002)
2. Ito, Hidemi: 4 articles (01/2019 - 04/2010)
3. Gera, Lajos: 4 articles (04/2012 - 09/2005)
4. Marceau, François: 4 articles (04/2012 - 09/2005)
5. Hosono, Satoyo: 3 articles (06/2016 - 04/2010)
6. Oze, Isao: 3 articles (06/2016 - 04/2010)
7. Tanaka, Hideo: 3 articles (06/2016 - 04/2010)
8. Watanabe, Miki: 3 articles (06/2016 - 04/2010)
9. Yatabe, Yasushi: 3 articles (06/2016 - 04/2010)
10. Tajima, Kazuo: 3 articles (07/2013 - 03/2002)

Related Diseases

1. Neoplasms (Cancer)
2. Chronic Obstructive Pulmonary Disease (COPD)
3. Lung Neoplasms (Lung Cancer)
08/01/2014 - "Meta-analysis of 30 studies suggested that individuals carrying Gln/Gln genotype were more likely than the individuals with Lys/Lys or Lys/Gln + Lys/Lys genotypes (homozygous model, OR 1.18, 95 % confidence interval (CI) 1.07-1.31; recessive model, OR 1.17, 95 % CI 1.06-1.29) to develop lung cancer, without any substantial heterogeneity. "
01/01/2014 - "This study suggests that heterozygous polymorphism (Lys/Gln) increases the sensitivity of lung cancer risk, while homozygous polymorphism (Lys/Lys) probably decreases its risk and C allele frequency shows no remarkable increase in the patients."
09/01/2010 - "Overall, significantly elevated lung cancer risk was associated with ERCC2 Gln allele when all studies were pooled into the meta-analysis (Lys/Gln versus Lys/Lys: odds ratio (OR)=1.10, 95% confidence interval (CI)=1.03-1.19; Gln/Gln versus Lys/Lys: OR=1.20, 95% CI=1.06-1.35; dominant model: OR=1.13, 95% CI=1.05-1.20; and recessive model: OR=1.15, 95% CI=1.03-1.29). "
01/01/2014 - "According to statistical analyses, lung cancer risk in individuals with Lys751Gln polymorphism (Odd Ratio=1.8, 95% Confidence Interval 0.848-3.819) is approximately twice as high as that of Lys/Lys genotype, however 751Gln/Gln genotype did not relate to lung cancer risk (Odd Ratio=0.7, 95% Confidence Interval 0/307-1/595). "
09/01/2013 - "In total, significantly increased risk of developing lung cancer was found in the following combinations of genotypes: XPD Lys/Gln+XPC Lys/Lys (OR = 1.62; p = 0.04), XRCC1 Gln/Gln+hOGG1 Ser/Ser (OR = 2.14; p = 0.02). "
4. Colorectal Neoplasms (Colorectal Cancer)
01/01/2013 - "This study suggests that individuals with heterozygous polymorphism (Lys/Gln) may have an increased susceptibility to colorectal cancer compared to other polymorphisms (Lys/Lys and Gln/Gln)."
10/15/2013 - "Overall, Lys939Gln was significantly associated with an increased overall cancer risk (Gln/Gln vs. Lys/Lys: OR = 1.16, 95% CI = 1.07 - 1.25, p < 0.001; recessive model: OR = 1.14, 95% CI = 1.06 - 1.22, p < 0.001; dominant model: OR = 1.06, 95% CI = 1.01 - 1.11, p = 0.015 and Gln vs. Lys: OR = 1.07, 95% CI = 1.03 - 1.10, p < 0.001) and further stratifications showed an increased risk for bladder, lung and colorectal cancer, Asian populations and population-based studies. "
10/01/2011 - "Overall, no significantly elevated colorectal cancer risk was found in all genetic models when all studies were pooled into the meta-analysis (for Lys751Gln polymorphism: Lys/Gln vs. Lys/Lys, OR = 1.01, 95% CI = 0.90-1.14; Gln/Gln vs. Lys/Lys, OR = 1.04, 95% CI = 0.85-1.26; dominant model, OR = 1.03, 95% CI = 0.93-1.15; recessive model, OR = 1.04, 95% CI = 0.87-1.25; and for Asp312Asn polymorphism: Asp/Asn vs. Asp/Asp, OR = 1.11, 95% CI = 0.91-1.35; Asn/Asn vs. Asp/Asp, OR = 1.13, 95% CI = 0.87-1.47; dominant model, OR = 1.09, 95% CI = 0.94-1.26; recessive model, OR = 1.11, 95% CI = 0.88-1.41). "
01/01/2009 - "The frequencies of genotypes: Glu/Glu, Glu/Lys and Lys/Lys were 41.7% (35/84), 41.7% (35/84) and 16.6% (14/84), respectively, in the gastric cancer cases, and 42.7% (35/82), 36.6% (30/82) and 20.7% (17/82), respectively, in the colorectal cancers. "
5. Tics (Tic)
09/01/2005 - "A similar distortion of apparent potency was observed for some peptide antagonists used in the contractility assay, B-10350 (Lys-Lys-[Hyp(3), Igl(5), d-Tic(7), CpG(8)]des-Arg(9)-BK) and Lys-[Leu(8)]des-Arg(9)-BK being intensely potentiated by amastatin treatment and effective L-Ala-p-nitroanilide competitors. "
01/05/2003 - "Des-Arg(9) bradykinin enhanced the magnitude of the electrically evoked contractions and this effect (which was sensitive to blockade by the peptide bradykinin B(1) receptor selective antagonist B9858, Lys-Lys-(Hyp(3),Cpg(5),D-Tic(7),Cpg(8))des-Arg(9) bradykinin) was only observed following a pre-incubation period and was greatest following 5 h of pre-incubation. "
02/01/2008 - "We previously developed a highly potent and selective BK B1R receptor antagonist, B9958 (Lys-Lys-[Hyp3, CpG5, d-Tic7, CpG8]des-Arg9-BK) (Hyp, trans-4-hydroxyproline; CpG, alpha-cyclopentylglycine; Tic, tetrahydroisoquinoline-3-carboxylic acid). "
01/01/2016 - "In this study we optimized the selection of radiolabel-chelator complex to improve tumor uptake and tumor-to-background contrast of radiolabeled analogues of B9958 (Lys-Lys-Arg-Pro-Hyp-Gly-Cpg-Ser-d-Tic-Cpg), a potent B1R antagonist. "
04/01/2012 - "Antagonists (B(1)R: B-10376: CF-ε-ACA-Lys-Lys-[Hyp(3), CpG(5), D-Tic(7), CpG(8)]des-Arg(9)-BK; B(2)R: B-10380: CF-ε-ACA-D-Arg-[Hyp(3), Igl(5), D-Igl(7), Oic(8)]-BK and fluorescein-5-thiocarbamoyl (FTC)-B-9430) label the plasma membrane of cells expressing the cognate receptors. "

Related Drugs and Biologics

1. arginyllysine
2. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3. Cetuximab (Erbitux)
4. aspartyl-aspartic acid (Asp-Asp)
5. Proteins (Proteins, Gene)
6. Lysine (L-Lysine)
7. arginylproline
8. hydroxide ion
9. Bradykinin
10. hydroxyprolyl-glycine

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Lasers (Laser)