cyclam

02/18/2020 - "Cyclam-based antibacterial molecules eradicate Gram-negative superbugs with potent efficacy against human corneal infection."
11/01/2019 - "These data support a potential application of the nebramine-cyclam conjugate as an adjuvant for treating infections caused by P. "
11/01/2000 - "The octapeptide D-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-NH(2) ([D-Ala(1)]TNH(2)), an analog of peptide T (H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH) associated with CD(4)/T(4) receptors involved in human immunodeficiency virus infection, was combined with the chelating polyazamacrocycle 1,4,8,11-tetraazacyclotetradecane (cyclam) to afford the bifunctional ligand cyc-[D-Ala(1)]TNH(2). "

09/01/2013 - "The purpose of this study was to develop a clinically relevant orthotopic xenotransplantation model of pancreatic cancer and to perform a preclinical evaluation of a new positron emission tomography (PET) imaging probe, ⁶⁴Cu-labeled cyclam-RAFT-c(-RGDfK-)₄ peptide (⁶⁴Cu-RAFT-RGD), using this model. "

01/21/2002 - "Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth."
10/10/2020 - "Here, we proposed to achieve migration chain-treatment for metastatic tumors by introducing a cell adhesion molecules CD44 inhibitor (Star miR-34a) to deprive of cell migration capability on the basis of CXCR4 antagonism (cyclam monomer, CM). "
09/01/2013 - "Micro-positron emission tomography/contrast-enhanced computed tomography imaging of orthotopic pancreatic tumor-bearing mice using the αvβ₃ integrin tracer ⁶⁴Cu-labeled cyclam-RAFT-c(-RGDfK-)₄."
06/01/2002 - "The tumor uptake of these cyclam-based markers is approximately 10 times higher when they are labeled with copper isotopes than when labeled with (99m)Tc. "
01/01/2001 - "Technetium-99m labeled cyclam N-2'-methoxyethyl-2-(3'-nitro-1'-triazole) acetamide (cyclam AK 2123) has been synthesized, radiolabeled and characterized as a hypoxic tumor imaging agent. "

02/01/2021 - "Additionally, it can be reversibly turned off by dehydration to the {NH4 [NiII (cyclam)][FeIII (CN)6 ]}n (1 d) phase, which features the NiII -FeIII valence state over the whole temperature range, but responds to pressure by yielding NiIII -FeII above 1.06 GPa."
04/01/2019 - "The title compounds undergo two single-crystal-to-single-crystal transformations triggered by thermal dehydration leading to the [{Cu(cyclam)}6{(α-GeW11O39)Ln(H2O)(OAc)}2]·4H2O intermediate (2-Ln, where Ln = Eu or Er) and [Cu(cyclam)]0.5[{Cu(cyclam)}5.5{(α-GeW11O39)Ln(OAc)}2] (3-Ln, where Ln = Ce or Eu) final anhydrous phases, the latter evidencing a coordinatively unsaturated derivative of the dimeric archetype for the first time. "
11/05/2018 - "The coexistence of dehydration-driven charge transfer, magnetic interactions, and high proton conductivity was found in two bimetallic alternating CN-bridged chains {(H3O)[NiIII(cyclam)][MII(CN)6]·5H2O} n (M = Ru (1), Os (2); cyclam = 1,4,8,11-tetraazacyclotetradecane). "
07/21/2015 - "An alternating bimetallic {(H3O)[Ni(III)(cyclam)][Fe(II)(CN)6]·5H2O}n chain undergoes reversible dehydration at 40 °C accompanied by electron transfer which leads to Ni(II)-Fe(III) in about 50% of metal centres. "
11/05/2018 - "Dehydration-Triggered Charge Transfer and High Proton Conductivity in (H3O)[NiIII(cyclam)][MII(CN)6] (M = Ru, Os) Cyanide-Bridged Chains."

01/01/2020 - "Moreover, we observed significant inhibition of NO donor- or hypoxia-induced HIF-1α (hypoxia-inducible factor 1α) accumulation in breast cancer cells, as well as reduced vascular tube formation by endothelial cells pretreated with the trans-[Fe(cyclam)(NO)Cl]Cl2 complex. "
01/01/2021 - "In Vivo Albumin-Binding of a C-Functionalized Cyclam Platform for 64 Cu-PET/CT Imaging in Breast Cancer Model."
12/01/2018 - "Cyclam-Modified PEI for Combined VEGF siRNA Silencing and CXCR4 Inhibition To Treat Metastatic Breast Cancer."
01/01/2014 - "Cytotoxicity testing shows that these new cyclam-triazole-dye conjugates display little or no toxicity against either DLD-1 colon carcinoma cells or MDA-MB-231 breast carcinoma cells, suggesting a potential role for these and related systems in biological sensing applications."