SK&F 91488

RN given refers to parent cpd; structure given in first source; PI: APT (80-92) (not an active MH record; now NM)

Also Known As:

SK&F 91488, dihydrobromide; SK&F 91488, dihydrochloride; SK&F-91488; SKF 91488; SKF-91488; carbamimidothioic acid 4-(dimethylamino)butyl ester

Networked: 6 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Thiourea: 362
      - Dimaprit: 54
        SK&F 91488: 6
- Sulfur Compounds: 278
  - Thiourea: 362
    - Dimaprit: 54
      - SK&F 91488: 6

Experts

1.	Jochem, J: 1 article (11/2002)
2.	Jagodzińska, Julia: 1 article (05/2002)
3.	Jochem, Jerzy: 1 article (05/2002)
4.	Korzonek-Szlacheta, Ilona: 1 article (05/2002)
5.	Rybus-Kalinowska, Barbara: 1 article (05/2002)
6.	Zwirska-Korczala, Krystyna: 1 article (05/2002)

Related Diseases

1.	Hypotension (Low Blood Pressure) 05/01/2002 - "The subpressor dose of SKF 91488 (10 microg) evoked the increase in blood volumes necessary to induce hypotension of 40 and 20 mmHg and the action was accompanied by the rise in histamine concentrations in the hypothalamus (5.18 +/- 0.45 vs 4.23 +/- 0.41 nmol/g; p < 0.05) and medulla oblongata (0.41 +/- 0.05 vs 0.30 +/- 0.06 nmol/g; p < 0.05), with no changes in the cortical histamine concentrations (0.84 +/- 0.18 vs 0.75 +/- 0.17 nmol/g), compared to the control i.c.v. saline-treated group. " 05/01/2002 - "Influence of SKF 91488, histamine N-methyltransferase inhibitor, on the central cardiovascular regulation during controlled, stepwise hemorrhagic hypotension in rats." 11/01/2002 - "Endogenous central histamine, after SKF 91488 treatment, via activation of H, receptors produces reversal of hypotension, with improvement in the survival rate at 2 h after treatment, in rats subjected to critical haemorrhagic hypovolaemia." 11/01/2002 - "Endogenous central histamine-induced reversal of critical haemorrhagic hypotension in rats--studies with histamine N-methyltransferase inhibitor SKF 91488."
2.	Tachycardia (Tachyarrhythmias) 05/01/2002 - "In normotensive animals, HNMT inhibitor SKF 91488 produced dose-dependent (20-100 microg i.c.v.) pressor effect accompanied by tachycardia, similarly as exogenous histamine (0.5-5 microg i.c.v.) did. " 06/01/1984 - "Bilateral injection of the inhibitor of histamine-N-methyltransferase, SKF 91488, which is also known as homodimaprit (5 micrograms), into the preoptic area of the rat produced delayed hypertension, tachycardia and hyperthermia. "
3.	Virus Diseases (Viral Diseases) 05/01/1994 - "However, responses to aerosolized acetylcholine were unaffected by viral infection and SKF 91488. " 05/01/1994 - "SKF 91488 (10(-2) M, 90 breaths) potentiated the responses to histamine in noninfected animals, and the magnitude of augmented responses to histamine by SKF 91488 was similar to that by viral infection. "
4.	Infections 04/24/1998 - "Pretreatment of tissues with the histamine N-methyltransferase inhibitor SKF 91488 abolished the infection-induced potentiation, whereas, the diamine oxidase inhibitor aminoguanidine had no effect. "
5.	Hypertension (High Blood Pressure) 06/01/1984 - "Bilateral injection of the inhibitor of histamine-N-methyltransferase, SKF 91488, which is also known as homodimaprit (5 micrograms), into the preoptic area of the rat produced delayed hypertension, tachycardia and hyperthermia. "

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Histamine N-Methyltransferase
3.	Ovalbumin
4.	Amine Oxidase (Copper-Containing)
5.	Antigens
6.	Acetylcholine (Acetylcholine Chloride)
7.	pimagedine (aminoguanidine)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)