pazelliptine

RN given refers to parent cpd; structure given in first source

Also Known As:

1-gamma-diethylaminopropylamino-5-methyl-dipyrido (4,3-b)(3,4-f)indole; 10-(3-diethylaminopropylamino)-6-methyl-5H-pyrido(3',4'-4,5)pyrrolo(2,3-g)isoquinoline; BD 40; BD-40; DAPA-PPI; pazelliptine maleate (1:3); N,N-diethyl-N'-(6-methyl-5H-pyrido(3',4'-4,5)pyrrolo(2,3-g)isoquinolin-10-yl)-1,3-propanediamine

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - pazelliptine: 7
    - Isoquinolines: 34
      - pazelliptine: 7

Experts

1.	Dunne, C: 1 article (12/2007)
2.	Kay, E: 1 article (12/2007)
3.	Leader, M: 1 article (12/2007)
4.	Murphy, G M: 1 article (12/2007)
5.	O'Grady, A: 1 article (12/2007)
6.	O'Kelly, P: 1 article (12/2007)

Related Diseases

1.	Pathologic Complete Response 10/01/1996 - "A significant increase of sTM levels compared with control values (26 +/- 2 ng/ml) was found in active WG, TA, GCA, PAN, and BD: limited active WG: 63 +/- ng/ml; generalized active WG: 119 +/- 15 ng/ml; limited WG, partial remission: 60 +/- 5 ng/ml; generalized WG, partial remission: 75 +/- 7 ng/ml; active TA: 36 +/-; active GCA: 36 +/- 4 ng/ml, active PAN: 33 +/- 2 ng/ml, active BD: 40 +/- 4 ng/ml. Limited and generalized WG in complete remission did not have elevated levels of sTM. "
2.	Neoplasms (Cancer) 02/15/1997 - "Low light level fluorescence microscopy studies have been carried out on MCF7-P human mammary tumor cells to localize the intracellular distribution of two new anticancer drugs, Pazelliptine and Intoplicine, which are currently under clinical evaluation. " 05/01/1994 - "In the follow-up study reported here, the activities of cisplatin, AZQ (diaziquone), pazelliptine and retelliptine have been evaluated against a panel of 40 established tumor lines grown subcutaneously in nude mice. " 09/01/1984 - "BD-40 is a pyrido-pyrrolo-isoquinoline analogue of ellipticine, which possesses oncostatic in vivo activity on experimental tumors, and dose-dependent cytostatic and cytotoxic activities on mammalian cells in culture. " 05/01/1994 - "When activity was defined as a specific growth delay > 1 and a tumor growth inhibition > 50%, then cisplatin demonstrated activity in 15 of 40 xenografts tested (3 of 5 breast, 1 of 6 colon, 0 of 5 head+neck, 2 of 6 NSCLC, 4 of 7 SCLC, 1 of 5 melanoma and 4 of 6 ovarian cancers); AZQ was active in 23 of 38 xenografts (2 of 3 breast, 2 of 7 colon, 4 of 5 head+neck, 3 of 6 NSCLC, 6 of 6 SCLC, 2 of 5 melanoma, 4 of 6 ovarian cancers); pazelliptine was active in 2 of 38 xenografts (1 of 5 breast cancers, 1 of 5 melanoma) while retelliptine was active in 1 of 39 xenografts (a breast cancer xenograft) tested. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/01/2007 - "A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization. "
4.	Basal Cell Carcinoma (Rodent Ulcer) 12/01/2007 - "A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization. "
5.	Bowen's Disease (Disease, Bowen) 12/01/2007 - "A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization. "

Related Drugs and Biologics

1.	Tissue Inhibitor of Metalloproteinase-2
2.	Tissue Inhibitor of Metalloproteinase-1
3.	intoplicine
4.	ellipticine
5.	Cytostatic Agents
6.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
7.	Cisplatin (Platino)
8.	BR 76 (BR 1376)
9.	retelliptine (BD 84)
10.	isoquinoline