Collins' solution

solution resembling intracellular fluid used in perfusion of tissues or organs prior to freezing; contains 330mOsm./L.; other components listed in Urology; C-2 has high potassium content 1980;15(5):480

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Networked: 26 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Hypothermia 07/01/1977 - "[Comparison between physiological and morphological examinations of animal livers maintained in hypothermia and perfused with Collins solution]." 01/01/1976 - "Each kidney was perfused before and after storage at simple hypothermia with 25 ml of a modified Collins solution. " 06/23/1973 - "[Preparation of the kidney for its experimental preservation by hypothermia with a Collin's solution]." 04/01/1973 - "[A simple procedure for lung preservation: hypothermia at 4 degrees C after washing with Collins solution no. 3]." 03/01/1986 - "The effect of preserving the heart and lungs with hypothermia and Collins solution was studied in 13 mongrel dogs undergoing combined heart-lung transplantation. "
2.	Paralysis (Palsy) 09/01/1989 - "In 21 of selected relaxed heart models the energy phosphate pattern as an index of viability was measured by P-31 MRS on a 4.7 Tesla NMR tomograph in 37 experimental runs with the following perfusion protocols: 1) immediate cardioplegia with cold Bretschneider or Collins solution, transportation under cooling, MRS after approximately 1 h; 2) immediate cardioplegia, transportation, reperfusion with oxygenated warm blood, MRS; 3) immediate blood perfusion with genuine fresh arterial blood from the slaughterhouse, cold plegia perfusion, transportation, MRS; 4) immediate blood perfusion with transportation MRS; 4) immediate blood perfusion with genuinefresh arterial blood, cold plegia perfusion, transportation, reperfusion with oxygenated warm blood, MRS during reperfusion; 5) An experimental pig heart was made plegic in vivo and reperfused with oxygenated warm blood during MRS as reference.(ABSTRACT TRUNCATED AT 250 WORDS)" 01/01/1991 - "The aim of this study was to develop and test a new and simple kidney perfusion model from slaughterhouse swine using a new 4.7-tesla/40-cm diameter system, with the intention behind to provide a human-like mammalian experimental kidney perfusion model, and to avoid sensitive in vivo animal experiments on higher-developed mammalians, 35 pig kidneys obtained 10-15 min post mortem were studied to evaluate and define conditions for optimum metabolic preservation with the following perfusion protocols: (1) immediate plegia with cold Collins solution, 1-3 h cold storage, P-31 MRS; (2) immediate plegia, 1-3 h cold storage, blood reperfusion, P-31 MRS; (3) immediate blood reperfusion, plegia, 1-3 h cold storage, blood reperfusion, P-31 MRS; (4) immediate blood reperfusion, plegia, 24 h cold storage, blood reperfusion, P-31 MRS, P-31 MRS at 81 MHz with a double-tuned surface coil yielded the following results: [table: see text] Blood flow showed a weak correlation with beta-ATP/inorganic phosphate in protocols 3 and 4 of r = 0.64. "
3.	Ischemia 11/01/1991 - "Canine kidneys were subjected to 48 h of hypothermic ischemia (4 degrees C) after intravascular flush with cold conventional Collins solution (G. " 10/01/1989 - "To assess the effect of ischemia on osteocyte survival and longitudinal growth in bone, one forelimb of eight puppies and seven dogs was amputated, perfused with iced Collins solution, maintained at 4 degrees C for 72 hours (78.5 hours total anoxia), and replanted. " 01/01/1978 - "Hypothermic preservation in combination with single perfusion by means of Collins' solution without thermic ischemia caused loss of sodium, increase of potassium, and decrease of the total osmotic cortico-papillary gradient of the kidney. " 01/01/1978 - "In experiments on canine kidneys, cortical edema formation during hypothermic storage following a period of normothermic ischemia of up to 30 min duration was - according to the osmolality of the perfusion fluid - lower after flush perfusion with Sacks II solution than with Biotest-"Collins" solution or Ringer-mannitol solution, which resulted in the highest edema. "
4.	Flushing 05/01/1990 - "Heart-lung blocks were harvested after cardioplegic arrest, and a simple pulmonary artery flush of 4 degrees C modified Collins' solution was administered at 15 ml/kg/min. The lungs were ventilated with 100% nitrogen during flushing and inflation. " 10/01/1978 - "Canine kidneys, flushed with either Collins solution or autologous cryoprecipitated plasma, were then stored for 24 hr by either simple cold storage (submersion) in the flushing solution, or by continuous hypothermic pulsatile perfusion with cryoprecipitated plasma. " 06/01/1990 - "Livers were preserved by in situ flushing and cold storage with the following results: 56% of rats survived for 1 week after 9 hr of preservation with UW solution as compared with 44% using Marshall solution, and 10% using Collins solution. " 12/01/1975 - "Even a brief period of ischaemic produced a sharp fall in adenine nucleotide concentration: further fall was prevented by flushout with cold Ringer's solution and some restoration of nucleotides was achieved by flushing with a modified Collins' solution. "
5.	Heart Arrest (Cardiac Arrest) 01/01/1977 - "The authors present the first case of cardiac arrest, occurring at the time of vessel clamps removal, of a kidney transplantation cooled prior to grafting with Collin's solution. " 10/01/1988 - "[Induction of cardiac arrest before cold storage in Collins' solution--important role of the cardioplegic solution]."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Sodium
3.	Potassium
4.	Cardioplegic Solutions
5.	Adenine Nucleotides
6.	Lactic Acid (Lactate)
7.	Calcium
8.	Phosphates (Orthophosphate)
9.	Solutions
10.	Citric Acid (Citrate)

Related Therapies and Procedures

1.	Transplantation
2.	Induced Heart Arrest (Cardioplegia)
3.	Heart-Lung Transplantation
4.	Kidney Transplantation