nuclear protein H1(0)

10/01/1987 - "H1(0) may be a marker of malignant transformation of lymphocytes and as such could be of use for early detection of relapse in patients with acute lymphocytic leukemia in apparent complete remission."

11/01/2016 - "This study revealed the presence in A375 melanoma cells of at least three RBPs, with apparent MW of about 65, 45 and 38 kDa, which are able to bind H1.0 mRNA. "
11/01/2016 - "Herein we report that melanoma cells not only secrete EVs which contain a modified form of H1.0 histone, but also transport the corresponding mRNA. "
11/01/2016 - "Extracellular vesicles shed by melanoma cells contain a modified form of H1.0 linker histone and H1.0 mRNA-binding proteins."

06/20/2018 - "Interestingly, H1.0 or post-translational forms of it have been also found in extracellular vesicles (EVs) released from cancer cells in culture, thus suggesting that these cells may escape differentiation at least in part by discarding H1.0 through the EV route. "
01/01/2016 - "Self-renewing epigenetic states are not stable, and reexpression of H1.0 in subsets of tumor cells establishes transcriptional programs that restrict cancer cells' long-term proliferative potential and drive their differentiation. "
01/01/2016 - "Numerous cancer types exhibit high inter- and intratumor heterogeneity of H1.0, with H1.0 levels correlating with tumor differentiation status, patient survival, and, at the single-cell level, cancer stem cell markers. "
08/01/2013 - "The mean quantities of H1.0 were: 23.3 for grade II tumors, 13.9 for grade III and 11.3 for grade IV tumors. "
08/01/2002 - "Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression."

08/01/1992 - "We have studied the kinetics of H1(0) accumulation in mouse erythroleukemia (MEL) cells and found that the levels of H1(0) reflect the rate of cell proliferation rather than the state of differentiation. "
04/01/1996 - "Using B16 melanoma and Friend erythroleukemia cells, which can be induced to differentiate, I studied H1(0) mRNA translation regulation by measuring the H1(0) synthesis rate with radioactive labelling. "
01/09/1998 - "Individual anti-H1(0) monoclonal antibodies were screened in an immunolocalization assay to isolate clones able to recognize H1(0) in a differentiation-dependent manner using a murine erythroleukemia cell line. "
06/01/1991 - "The present paper provides evidence showing that, in murine erythroleukemia (MEL) cells, H1(0) mRNA accumulation is coupled to DNA replication, but this mRNA is stable enough to remain present all over the cell cycle. "
06/01/1991 - "Cell cycle-related accumulation of H1(0) mRNA: induction in murine erythroleukemia cells."

06/01/1990 - "We have studied the steady-state levels of histone H1 (0) mRNA under varied growth conditions in the human hepatoma cell lines HepG2 and Hep3B, and we show in the HepG2 system that H1 (0) is not confined to resting cells, that the H1 (0) gene appears to be expressed throughout the cell cycle and that established inducers of de novo H1 (0) synthesis fail to cause a further increase of the high H1 (0) level. "
08/01/1993 - "The 3' end of PCK, arylsulfatase A and H1(0) mRNA exhibited strong binding of cytosolic protein(s) from diverse rat tissues such as heart, liver and lung as well as Fao rat hepatoma cells. "