globotetraosylceramide

Also Known As:

GalNAc-1-3-Gal-1-4-Gal-1-4-Glc-cer; Gb4 globoside; Gb4 globotetraosyl ceramide; Gb4Cer; GbOse4Cer; SLT-IIv receptor; VT2vp1 receptor; globoside GL-4; globotetraosyl ceramide; Globoside I

Networked: 20 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Müthing, Johannes: 2 articles (01/2020 - 08/2012)
2.	Gazárková, Taťána: 1 article (11/2020)
3.	Jin, Chunsheng: 1 article (11/2020)
4.	Norlén, Olov: 1 article (11/2020)
5.	Santos, Licínia: 1 article (11/2020)
6.	Säljö, Karin: 1 article (11/2020)
7.	Teneberg, Susann: 1 article (11/2020)
8.	Thornell, Anders: 1 article (11/2020)
9.	Bien, Tanja: 1 article (01/2020)
10.	Conrad, Anja: 1 article (01/2020)

Related Diseases

1.	Pyelonephritis 02/01/1987 - "The frequency of positive reactions among the pyelonephritis isolates was 78.5% with the globotetraosylceramide-latex reagent, compared with 41% for the cystitis isolates, 25% for the asymptomatic bacteriuria isolates, and 13% for the fecal isolates. " 01/01/1982 - "Glycolipids including globotetraosylceramide and globotriaosylceramide, which contain the disaccharide Gal alpha 1 leads to 4Gal were bound by many strains isolated from patients with pyelonephritis and cystitis. " 02/01/1987 - "In the present study, the reactivity with Gal alpha 1----4Gal beta-latex [galactose alpha (1----4)galactose beta-latex] and globotetraosylceramide-latex was analyzed for strains from patients with acute pyelonephritis (n = 135), acute cystitis (n = 121), and asymptomatic bacteriuria (n = 119) and from the fecal flora of healthy children (n = 120) and compared with agglutination of human blood group P1 and p, as well as guinea pig, erythrocytes. "
2.	Cystitis 02/01/1987 - "The frequency of positive reactions among the pyelonephritis isolates was 78.5% with the globotetraosylceramide-latex reagent, compared with 41% for the cystitis isolates, 25% for the asymptomatic bacteriuria isolates, and 13% for the fecal isolates. " 01/01/1982 - "Glycolipids including globotetraosylceramide and globotriaosylceramide, which contain the disaccharide Gal alpha 1 leads to 4Gal were bound by many strains isolated from patients with pyelonephritis and cystitis. " 02/01/1987 - "In the present study, the reactivity with Gal alpha 1----4Gal beta-latex [galactose alpha (1----4)galactose beta-latex] and globotetraosylceramide-latex was analyzed for strains from patients with acute pyelonephritis (n = 135), acute cystitis (n = 121), and asymptomatic bacteriuria (n = 119) and from the fecal flora of healthy children (n = 120) and compared with agglutination of human blood group P1 and p, as well as guinea pig, erythrocytes. "
3.	Autosomal Dominant Polycystic Kidney (ADPKD) 07/02/2013 - "Application of the method for detailed investigation of Gb4Cer isoforms in kidneys of an ADPKD rat model revealed increased levels of sphingoid base-containing isoforms in cystic kidneys, whereas changes were subtle for Gb4Cer-containing phytosphingoid bases. " 07/02/2013 - "We furthermore established an absolute LC-ESI-MS/MS quantification method and demonstrate that absolute quantities of Gb4Cer correlate well with relative quantities obtained by indirect TLC-MALDI-TOF-MS. Taken together, our study proposes an effective sample preparation method for automated analysis of lipid extracts and TLC eluates and suggests that indirect high-performace (HP)TLC-MALDI-TOF-MS with automated data acquisition is a viable option for analysis of neutral glycosphingolipids and that Gb4Cer may play a role in the pathogenesis of ADPKD. " 07/02/2013 - "In contrast to glucosylceramide and gangliosides, alterations in complex neutral GSLs such as globotetraosylceramide (Gb4Cer) have not been investigated in ADPKD yet, and mass spectrometry analysis of Gb4Cer from tissue extracts remains challenging. "
4.	Bacteriuria 02/01/1987 - "The frequency of positive reactions among the pyelonephritis isolates was 78.5% with the globotetraosylceramide-latex reagent, compared with 41% for the cystitis isolates, 25% for the asymptomatic bacteriuria isolates, and 13% for the fecal isolates. " 02/01/1987 - "In the present study, the reactivity with Gal alpha 1----4Gal beta-latex [galactose alpha (1----4)galactose beta-latex] and globotetraosylceramide-latex was analyzed for strains from patients with acute pyelonephritis (n = 135), acute cystitis (n = 121), and asymptomatic bacteriuria (n = 119) and from the fecal flora of healthy children (n = 120) and compared with agglutination of human blood group P1 and p, as well as guinea pig, erythrocytes. "
5.	Neoplasms (Cancer) 01/01/2020 - "Using MALDI-2 and StxB-based immunofluorescence microscopy, Gb3Cer and Gb4Cer were mainly found in dedifferentiated tumor cell areas, tumor stroma, and tumor-infiltrating blood vessels. " 01/01/2017 - "Similarly, there were two bands on TLC of Gb4Cer from well-differentiated cancer, but only one band in poorly differentiated cancer, and the long-chain base of ceramide was observed to contain phytosphingosine in well-differentiated cancer. " 04/01/1987 - "The cancer tissues and the uninvolved mucosae did not contain galabiosylceramide, globotriaosylceramide, or globotetraosylceramide after separations by both thin layer chromatography and gas-liquid chromatography. " 04/01/1987 - "Immunostaining revealed the presence of globotriaosylceramide, globotetraosylceramide, Forssman glycolipid, and A active glycolipids in the cancer tissues. " 08/01/2012 - "The identification of Gb3Cer as a tumor-associated GSL in human pancreatic cancer prompted us to investigate the expression of Gb3Cer and Gb4Cer in 15 human pancreatic ductal adenocarcinoma cell lines derived from primary tumors and liver, ascites, and lymph node metastases. "

Related Drugs and Biologics

1.	Neutral Glycosphingolipids
2.	Blood Group Antigens (Blood Groups)
3.	Lipids
4.	Latex
5.	Galactose (Galactopyranose)
6.	globotriaosylceramide (globotriosylceramide)
7.	globotetraosylceramide
8.	Glucosylceramides (Glucocerebrosides)
9.	Glycosphingolipids
10.	Glycolipids