nevadensin

12/01/2014 - "This study investigated whether the inhibitory effect of the basil flavonoid nevadensin on sulfotransferase (SULT)-mediated bioactivation of methyleugenol observed in vitro would also be reflected in a reduction of DNA adduct formation and a reduction in an early marker for liver carcinogenesis in an 8-week rat study. "

05/27/2023 - "RNAseq analysis showed that nevadensin regulates multiple functional signaling pathways associated with cancer including Hippo signaling. "
05/27/2023 - "Nevadensin, a bioflavonoid, exhibits anti-cancer properties in some cancers. "
12/01/2014 - "These results suggest that tumor formation could be lower in rodent bioassays when methyleugenol would be dosed in a matrix containing SULT inhibitors such as nevadensin compared to experiments using the pure methyleugenol. "
12/01/2014 - "Co-exposure to methyleugenol and nevadensin orally resulted in a significant inhibition of liver methyleugenol DNA adduct formation and in inhibition of hepatocellular altered foci induction, representing indicators for initiation of neoplasia. "
06/01/2010 - "The results predict that co-administration of estragole at a level inducing hepatic tumors in vivo (50mg/kg bw) with nevadensin at a molar ratio of 0.06, representing the ratio of their occurrence in basil, results in almost 100% inhibition of the ultimate carcinogen 1'-sulfooxyestragole when assuming 100% uptake of nevadensin. "

10/01/1981 - "[Synthesis of Nevadensin analogues and their anti-tuberculosis activity (author's transl)]."

12/01/2021 - "The results suggest that cell cycle disruption and apoptotic events play key roles in the cellular response to TOPO I poisoning caused by nevadensin in HT29 cells."
12/01/2021 - "Topoisomerase poisoning by the flavonoid nevadensin triggers DNA damage and apoptosis in human colon carcinoma HT29 cells."

05/27/2023 - "We aim to evaluate the efficacy as well as the molecular mechanism of nevadensin in the treatment of liver cancer. "
05/27/2023 - "However, the precise underlying mechanism of nevadensin against liver cancer are poorly understood. "