monodehydroascorbate reductase (NADH)

Also Known As:

AFR reductase; MDA reductase; NADH ascorbate free radical reductase; NADH semidehydroascorbate oxidoreductase; SDAR enzyme; ascorbic free radical reductase; semidehydroascorbate reductase

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - NADPH Oxidoreductases NADH
      - monodehydroascorbate reductase (NADH): 3

Related Diseases

1.	Wounds and Injuries (Trauma) 05/01/1995 - "In addition, AFR reductase may contribute to maintaining levels of ascorbic acid for protection against wound-induced free radical-mediated damage. "
2.	Neuroblastoma 03/01/1998 - "The present study investigated the ability of two neuroblastoma cell lines (SK-N-SH, with one copy of N-myc, and SK-N-BE(2), with over 150 copies of N-myc) to recycle ascorbate by quantifying semidehydroascorbate reductase and dehydroascorbate reductase activities. "
3.	Cataract (Cataracts) 01/01/1988 - "The above results suggested that AFR reductase in the human lens plays important roles in ascorbate regeneration of its redox cycle, and that activity loss of AFR reductase, as well as of superoxide dismutase, glutathione peroxidase and glutathione reductase, may be responsible for the oxidative changes in lens proteins with the development of senile cataracts."

Related Drugs and Biologics

1.	Free Radicals
2.	Ascorbic Acid (Vitamin C)
3.	glutathione dehydrogenase (ascorbate)
4.	Superoxide Dismutase
5.	Glutathione Reductase (Glutathione-Disulfide Reductase)
6.	Glutathione Peroxidase
7.	Crystallins (Crystallin)