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1 alpha,24-dihydroxyvitamin D3 (Tacalcitol)

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RN refers to (1alpha,3beta,5Z,7E)-isomer; formulated in ointment at a concentration of 4 microg/g, for treatment of mild psoriasis

Also Known As:

Tacalcitol; 1 alpha,24-dihydroxycholecalciferol; 1 alpha,24-dihydroxyvitamin D3, (1alpha,3beta,5Z,7E,24R)-isomer; 1 alpha,24-dihydroxyvitamin D3, (1alpha,3beta,5Z,7E,24S)-isomer; 1,24-dihydroxycholecalciferol; 1,24-dihydroxyvitamin D3; Curatoderm; PRI-2191; (1 alpha,3 beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,24-triol

Networked: 106 relevant articles (34 outcomes, 37 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Kutner, Andrzej: 15 articles (01/2015 - 01/2002)
2.	Wietrzyk, Joanna: 9 articles (01/2015 - 09/2004)
3.	Milczarek, Magdalena: 5 articles (08/2014 - 10/2008)
4.	Ishikawa, Osamu: 5 articles (08/2010 - 02/2005)
5.	Abe, Masatoshi: 4 articles (08/2010 - 02/2005)
6.	Opolski, Adam: 4 articles (04/2007 - 09/2004)
7.	Maciejewska, Magdalena: 3 articles (02/2013 - 10/2008)
8.	Yokoyama, Yoko: 3 articles (08/2010 - 02/2006)
9.	Sogabe, Yoko: 3 articles (01/2008 - 02/2005)
10.	Budziszewska, Bogusława: 3 articles (07/2007 - 03/2005)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 07/01/2005 - "Tacalcitol was highly effective in the symptomatic treatment of moderate psoriasis. " 02/01/2004 - "The results of this study indicate that topical application of tacalcitol (4 micro g/g) emulsion once daily is an effective, safe and very well- tolerated treatment for scalp psoriasis." 01/01/2009 - "Treatment with tacalcitol ointment may be useful to treat nail psoriasis as it achieves a significant improvement in all nail parameters, both of the matrix and of the bed." 02/01/2004 - "Tacalcitol was significantly superior to placebo in reducing the severity of scalp psoriasis. " 09/01/2002 - "Long-term safety and efficacy of high-concentration (20 microg/g) tacalcitol ointment in psoriasis vulgaris."
2.	Vitiligo 12/01/2006 - "To study and compare the efficacy of combined 308-nm monochromatic excimer light (MEL) therapy with tacalcitol vs. that of MEL 308-nm therapy alone in treatment of vitiligo. " 02/01/2009 - "Randomized, double-blind clinical trial to evaluate the efficacy of topical tacalcitol and sunlight exposure in the treatment of adult nonsegmental vitiligo." 12/01/2006 - "Our results have shown that concurrent topical tacalcitol potentiates the efficacy of the 308-nm MEL in the treatment of vitiligo, and that this combination achieves earlier pigmentation with a lower total dosage." 03/01/2006 - "Addition of topical tacalcitol to NB-UVB treatment improved the extent of repigmentation and increased the response rate in patients with vitiligo compared with NB-UVB treatment alone. " 09/01/2012 - "Freckling promoted by topical tacalcitol in a Japanese boy with left eyelid vitiligo."
3.	Inflammation 07/01/2003 - "In this study, tacalcitol ointment (20 micro g/g) was found to have a marked effect on cutaneous inflammation and improved effect on epidermal differentiation, although tacalcitol ointment (2 micro g/g) also had significant effects on epidermal proliferation and differentiation. " 03/01/2004 - "In this study, tacalcitol was found to have an inhibitory effect on cutaneous inflammation such as inhibition of neutrophil infiltration, MIP-2 and KC production, and mast cell degranulation in TPA-treated hairless mice. " 06/01/2010 - "These findings suggest that tacalcitol reduces skin inflammation by partially downregulating CLA expression levels." 07/01/2003 - "Tacalcitol ointment (0, 2 and 20 micro g/g) significantly inhibited 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced cutaneous inflammation, histopathologically. " 07/01/2003 - "Pharmacological profiles of high-concentration (20 microg/g) tacalcitol ointment: effects on cutaneous inflammation, epidermal proliferation, and differentiation in mice."
4.	X-Linked Ichthyosis (Ichthyosis, X Linked) 01/01/2001 - "The object of the study was to assess the clinical efficacy of topical tacalcitol against ichthyoses with retentive hyperkeratosis; X-linked ichthyosis (XLI), ichthyosis vulgaris (IV), and acquired ichthyosis (AI). "
5.	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris) 01/01/2001 - "The object of the study was to assess the clinical efficacy of topical tacalcitol against ichthyoses with retentive hyperkeratosis; X-linked ichthyosis (XLI), ichthyosis vulgaris (IV), and acquired ichthyosis (AI). "

Related Drugs and Biologics

1.	calcipotriene (calcipotriol)
2.	Betamethasone (Celestone)
3.	Calcitriol (Calcijex)
4.	Ointments (Pastes)
5.	Coal Tar (Estar)
6.	Vitamin D
7.	hydroxide ion
8.	Cholecalciferol (Vitamin D3)
9.	betamethasone-17,21-dipropionate (betamethasone dipropionate)
10.	maxacalcitol

Related Therapies and Procedures

1.	PUVA Therapy
2.	Phototherapy (Light Therapy)
3.	Excimer Lasers
4.	Photochemotherapy (Photodynamic Therapy)
5.	Occlusive Dressings (Occlusive Dressing)