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quinonyl-MDP-66
Also Known As:
QMDP 66; quinonyl-N-AcMu-Val-iso-Gln-methyl ester; quinonyl-N-acetylmuramyl-L-valyl-D-isoglutamine methyl ester; D-alpha-Glutamine, N2-(N-(N-acetyl-6-O-(10-(4,5-dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-1-oxodecyl)muramoyl)-L-valyl)-, methyl ester
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Carbohydrates: 22023
Amino Sugars: 110
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
quinonyl-MDP-66: 4
Sugar Acids: 4
Muramic Acids: 28
Acetylmuramyl-Alanyl-Isoglutamine: 467
quinonyl-MDP-66: 4
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Glycopeptides: 1928
Acetylmuramyl-Alanyl-Isoglutamine: 467
quinonyl-MDP-66: 4
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
01/01/1986 - "
The reconstituted suspension of quinonyl-MDP-66 in oil-in-water emulsion was stable for more than 24 hrs. The oil-in-water emulsion of quinonyl-MDP-66 as prepared above was effective for the distribution of quinonyl-MDP-66 into regional lymph node in rats and for the regression of line 10 hepatoma in strain 2 guinea pigs by intralesional injection.
"
2.
Neoplasms (Cancer)
01/01/1983 - "
However, primary tumor size and the numbers of lung metastases were not affected when quinonyl-MDP-66 was administered under the present experimental conditions.
"
01/01/1986 - "
The pharmaceutical properties of quinonyl-MDP-66 were discussed with special reference to the stability of oil-in-water emulsion, distribution capacity into regional lymph nodes and tumor regressive activity.
"
05/01/1983 - "
Mouse peritoneal macrophages, when treated either in vitro or in vivo with quinonyl-MDP-66 suspended in phosphate-buffered saline, showed a capacity for cytolysis and cytostasis against tumor targets and released H2O2 in the presence of phorbol myristate acetate.
"
01/01/1981 - "
The effectiveness of the chain length of the quinonyl moiety in quinonyl-MDP-66 and the replacement of the L-valine residue with L-serine or L-threonine were also examined in comparison with the adjuvant and tumor-suppressive activities of quinonyl-MDP-66.
"
3.
Lewis Lung Carcinoma
01/01/1983 - "
Quinonyl-MDP-66 suspended in phosphate-buffered saline was shown to restore the depressed allogeneic cell-mediated cytotoxicity of spleen cells from mice with Lewis lung carcinoma when the chemical was injected twice intraperitoneally, intravenously, or intratumorally.
"
01/01/1983 - "
Intraperitoneal injection of quinonyl-MDP-66 in mice with Lewis lung carcinoma enhanced host resistance to Listeria monocytogenes infection.
"
4.
Neoplasm Metastasis (Metastasis)
01/01/1983 - "
However, primary tumor size and the numbers of lung metastases were not affected when quinonyl-MDP-66 was administered under the present experimental conditions.
"
5.
Infections
01/01/1983 - "
Intraperitoneal injection of quinonyl-MDP-66 in mice with Lewis lung carcinoma enhanced host resistance to Listeria monocytogenes infection.
"
Related Drugs and Biologics
1.
Suspensions
2.
Emulsions
3.
Phosphates (Orthophosphate)
4.
Valine (L-Valine)
5.
Threonine (L-Threonine)
6.
Tetradecanoylphorbol Acetate
7.
Serine (L-Serine)
Related Therapies and Procedures
1.
Intralesional Injections
2.
Intraperitoneal Injections